Katzung 12th ed - Chapter 50 - Metronidazole, Disinfectants (2) Flashcards Preview

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Flashcards in Katzung 12th ed - Chapter 50 - Metronidazole, Disinfectants (2) Deck (9):
1

Name some anaerobes that are susceptible to metronidazole.

Bacteroides, Clostridium, Trichomonas, Giardia, Amoebiasis.

2

Describe the distribution of metronidazole in tissues.

Metronidazole is widely distributed, and penetrates well into CSF.

3

What is the route of metabolism of metronidazole?

Hepatic.

4

Name some routes of administration of metronidazole (up to four)

Oral, IV, rectal suppository, vaginal gel (for vaginitis).

5

Half-life of metronidazole?

7 hours.

6

One side effect of metronidazole?

Metallic taste in the mouth.

7

What is the definition of an antiseptic?

An antiseptic is a disinfectant with sufficiently low toxicity to allow use directly on the skin, mucous membranes and wounds.

8

What is autoclaving?

Sterilisation using pressurised steam at 120 degrees for 20 minutes.

9

What type of disinfectant is required to clean a room contaminated with Clostridium difficile spores?

Concentrated bleach (5000ppm) – which is chlorine. Alcohol should not be used because it would not kill the spores.

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