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HYMS Y4 > KEY ANTIBODIES + PATHOGNOMONIC BLOODS > Flashcards

KEY ANTIBODIES + PATHOGNOMONIC BLOODS Flashcards

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1
Q

Autoimmune hepatitis type 1

A

Anti-actin
ANA
Anti-SLA/LP
SMA

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2
Q

Autoimmune hepatitis type 2

A

anti-LKM1

anti-LC1

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3
Q

PSC

A

p-ANCA

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4
Q

PBC

A

AMA

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5
Q

Wilson’s disease

A

Caeruloplasmin

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6
Q

Hereditary haemochromatosis

A

Raised ferritin

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7
Q

Active hep B infection

A

HBsAg

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8
Q

Current or previous hep B infection

A

HBcAb

IgM = current
IgG = previous
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9
Q

Core hep B antigen

A

HBcAg

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10
Q

active replication of hep B infection

A

HBeAg

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11
Q

antibody showing that hep B has stopped replicating

A

HBeAb

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12
Q

vaccination against hep B

A

HBsAb

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13
Q

direct count of hep B viral load

A

HBV DNA

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14
Q

screening tests for hep B

A

HBcAb + HBsAg

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15
Q

tests done if hep B screening positive

A

HbeAg + HBV DNA

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16
Q

Coeliac disease

A

anti-TTG/ anti-EMA

**MUST check IgA first.

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17
Q

Myaesthenia gravis

A

Anti-ACh antibodies
Anti-MUSK
Anti-LPR4

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18
Q

Churg-strauss syndrome (eosinophilic granulomatosis with polyangiitis)

A

pANCA
eosinophils >10%

(+ asthma + paranasal sinusitis + pulmonary infiltrates)

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19
Q

Lambert-Eaton syndrome

A

Antibodies to voltage gated calcium channels

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20
Q

Membranous glomerulonephritis.

A

Anti-phospholipase A2 receptor antibody.

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21
Q

Post-streptococcal glomerulonephritis.

A

Anti-streptolysin O titres.
Anti-DNAase B
Decreased serum C3

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22
Q

Systemic lupus erythematosus.

A

ANA

Anti-dsDNA

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23
Q

Granulomatosis with polyangiitis.

A

c-ANCA.

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24
Q

Microscopic polyangiitis.

A

p-ANCA.

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25
Goodpastures disease.
Anti-GBM antibodes.
26
Grave's disease.
Anti-TPO antibodies. | TSH receptor antibodies.
27
Hashimoto's thyroiditis.
Anti-TPO antibodies. | Anti-thyroglobulin antibodies.
28
Myasthenia gravis.
Anti-ACh Anti-MUSK antibodies Anti-LRP4 antibodies
29
Rheumatoid arthritis.
RF | Anti-CCP.
30
Multiple sclerosis.
Oligoclonal bands in CSF.
31
Clotting test pattern in haemophilia?
APTT prolonged. | PT, thrombin time + bleeding time all normal.
32
Clotting test pattern in von willebrand disease?
APTT prolonged PT normal Bleeding time prolonged
33
Eosinophilic granulomatosis with polyangiitis.
p-ANCA.
34
Iron deficiency anaemia.
Low serum iron. Low ferritin. High transferrin/ TIBC
35
Anaemia of chronic disease.
Low/ normal serum iron. Low/ normal ferritin. Low transferrin/ TIBC.
36
Sideroblastic anaemia.
Ringed sideroblasts (iron-engorged peri-nuclear mitochondria in developing RBCs).
37
Pernicious anaemia.
Increased IgA antibodies against intrinsic factor/ parietal cells.
38
Hereditary spherocytosis.
Circular cells Low Hb Raised reticulocytes.
39
G6PD deficiency.
Heinz bodies.
40
Warm AIHA.
IgG
41
Cold AIHA.
IgM.
42
AML/ acute pro-myelocytic leukaemia.
Auer rods.
43
AML blood film.
Auer rods. | Blast cells.
44
CML.
Leukoerythroblasts.
45
Myelofibrosis.
Tear drop poikilocytosis.
46
CLL.
Smear/ smudge cells.
47
Myeloma.
Rouleaux formation. | BJPs.
48
Hodgkin's lymphoma.
Reed-Sternberg cells.
49
Burkitt's lymphoma.
Starry-sky appearance on blood film.
50
Polycythaemia vera.
Isolated rise in RBC count.
51
Von Willebrand's disease clotting profile.
Prolonged APTT Normal PT Prolonged bleeding time
52
Von Willebrand's disease.
Reduced VIII and reduced VWF.
53
Haemophilia clotting profile.
Prolonged APTT | Normal PT
54
Relationship between all spondyloarthropathies?
HLAB27
55
Gout joint aspiration?
Negatively birefringent, needle shaped, monosodium rate crystals.
56
Pseudogout joint aspiration?
Positively birefringent, rhomboid shaped, calcium pyrophosphate crystals.
57
SLE.
Sensitive? ANA. Specific? anti-dsDNA/ anti-smith Others: low C3 and C4
58
Antiphospholipid syndrome?
Anticardiolipin antibodies | Anti-beta-2 glycoprotein I antibodies.
59
Limited cutaneous systemic sclerosis (CREST syndrome).
Anti-centromere antibodies.
60
Diffuse cutaneous systemic sclerosis.
Anti-Scl-70 antibodies.
61
Sjogren's syndrome.
Anti-Ro + Anti-La antibodies.
62
Dermatomyositis.
Anti-Mi-2 antibodies ANA SOMETIMES Anti-Jo-1 antibodies.
63
Polymyositis.
Anti-Jo-1 antibodies.
64
Granulomatosis with polyangiitis.
cANCA.
65
Microscopic polyangiitis.
pANCA.
66
Eosinophilic granulomatosis with polyangiitis.
pANCA.
67
MEN type 1 presentation.
``` Parathyroid problems (hyperparathyroidism) Pituitary problems Pancreas problems (insulinoma) ```
68
MEN type 1 gene.
MEN 1 gene.
69
Most common presentation of MEN 1.
Hypercalcaemia.
70
MEN type 2a presentation.
Medullary thyroid cancer Parathyroid problems Phaeochromocytoma.
71
MEN type 2 gene?
RET oncogene.
72
MEN type 2b presentation.
Medullary thyroid cancer Phaeochromocytoma Marfanoid body Neuromas
73
Most common thyroid cancer.
Papillary.
74
Thyroid cancer associated with Hashimoto's thyroiditis.
Lymphoma.
75
Blood clotting results in haemophilia?
APTT prolonged | PT and bleeding time normal.
76
Blood clotting results in von Willebrand's disease?
APTT increased PT normal Bleeding time increased
77
Blood clotting results in vitamin K deficiency?
APTT increased PT increased Bleeding time normal
78
Primary and tertiary hyperparathyroidism.
High PTH | High Calcium.
79
Secondary hyperparathyroidism.
High PTH | Low Calcium
80
Drug-induced lupus.
Anti-histone antibodies.

HYMS Y4 (8 decks)

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