Key concepts: Heart Development Flashcards

1
Q

what is seen from superior view of the embryo

A

cranial aspect
caudal aspect

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2
Q

cranial aspect

A

thickening of the mesoderm infront of the pro caudal plate

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3
Q

what does the heart tube develop from

A

the splanchnic layer of the lateral plate mesoderm

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4
Q

what does the endoderm release

A

vascular endothelial growth factors
VEGF’s

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5
Q

function of VEGF’s

A

stimulates the differentiation of the lateral plate mesoderm
outer and inner core

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6
Q

outer core

A

angioblast cells
form blood vessels and heart tube

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7
Q

inner core

A

hemocytoblast
form blood cells

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8
Q

heart tube and pericardial cavities from 2 to 1

A

lateral folding occurs
layers fuse
form one of each

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9
Q

what is the dorsal mesocardium

A

connects th pericardial cavity to the heart tube

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10
Q

layers of the heart tube from outside to inside

A

endocardium
cardiac jelly
myocardium

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11
Q

endocardium

A

made from angioblasts

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12
Q

cardiac jelly

A

made from myocardium secretion

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13
Q

myocardium

A

made from the cardiac monocytes

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14
Q

what occurs during cranial caudal folding

A

the heart moves into the cranial cavity
and the heart tube into the pericardial cavity

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15
Q

label the heart tube top to bottom

A

aortic sac
truncu arteriosus
bulbos cordis
primitive ventricles
primitive atria
sinus venosus

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16
Q

aortic sac

A

leaves via the dorsal aortae

17
Q

trunks arteriosus

A

becomes the pulmonary trunk and the ascending aorta

18
Q

bulbs cordis

A

right ventricles
right and left ventricular outflow tracts

19
Q

primitive ventricle

A

left ventricle

20
Q

primitive atria

A

left and right atrium

21
Q

sinus venosus

A

have left and right horns
and 3 veins entering

22
Q

label the veins entering the sinus venosus from lateral to medial

A

common cardinal
umbilical
viterline

23
Q

heart formation

A

cardiac looping
AV canal formation
separating primtive atria
separate the BC and PV
inflow tracts
forming outflow tracts
semi-lunar valve formation

24
Q

importance of cardiac looping

A

dependent on dyneins
if absent then the heart will bend left and not right

25
process of cardiac looping
TA and BC move down and to the right PA moves to the left of the midline as TA and BC continue their movement PA moves backwards and upwards PA now up either side of the TA, attached to SV below the BC SV allows cells to move into pericardial cavity and forms visceral pericardium SV also allows cells to move into the "heart" forming the primitive conduction system
26
AV canal formation
AV sulcus between the PV and PA neural crest cells forming dorsal and ventral endocardial cushions cushions fuse to form the septum intermedium 2 canals form either side called the right and left AV canals connected by annulus ring, valve flaps cordinae tendinae come off valvulpus apparatus becomes bi and tricuspid
27
separating primitive atria
septum primum tries to reach from the top to the septum intermedium doesnt reach and forms hole known as ostium primum septum prinum eventually closes the ostium prinum another hole develops near the top which is the ostium secundum more tissue grows to try and block the ostium secundum there is still a small hole called the foramen ovale which eventually closes when born some division formed so can classify as right and left atrium
28
separating the BC and PV
at the heart the apex develops muscular portion of interventricular septum grows into the heart space between= membranous portion of inter ventricular septum comes from septum intermedium, closed gap BC (one part of this) becomes the RV PV becomes the LV
29
inflow tracts
between the PA and SV all veins on the left horn of SV break down leaving left horn umbilical horn degenerates leaving CCV and V left horn shifts towards right horn and fuses before entering the SV SV absorbed to become PA left horn becomes coronary sinus right common cardinal becomes superior vena cava right vitelline vein to the inferior vena cava
30
outflow tract formation
neural crest cells form 2 truncal ridges in the TA and 2 bulbar ridges in the BC also ridge in the middle of TA and BC 2 ridges one is dorsal and the other is ventral meet in the middle when ridges approach they spiral around central axis ridges in the TA fuse to form the septum ridges in the BC fuse to form septum ridges in middle form septum causes corkscrew of TA and BC to form aorticopulmonary septum as blood moves LV through posterior portion of the septum crosses behind then infront of the top portion to form aortic arch RV moves anterior, cross then posterior to form pulmonary trunk structure rotates and splits structures
31
semi lunar valve formation
cross section at the bulbis cordis and conus cordis junction neural crest cells form endothelial cushions (left right dorsal ventral) during rotation vagination occurs splits cushions left and right then splits entirely into dorsal and ventral still have full dorsal ventral cushion but half right and left cushion dorsal= left ventricular outflow tract= aorta ventral= right VOT= pulmonary trunk forms semilunar valves rotation occurs
32
right hand side post rotation
aortic SLV LVOT