Kidd (009) Blood Group System Flashcards Preview

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Flashcards in Kidd (009) Blood Group System Deck (18)
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1
Q

Notorious for causing hemolytic transfusion reaction (delayed type)

A

Kidd (Jk)

2
Q

Gene location of Kidd

A

Chromosome 18q

3
Q

Antithetical antigens of kidd

A

Jka and Jkb

4
Q

Well developed at birth as early as

A

11th week: jka
7th week: jkb

5
Q

Not found in platelets and WBCS.
Unaffected by chloroquine, DTT,AET,glycine-acid EDTA.

A

Kidd antigens

6
Q

They demonstrate dosage, are often weak, and are found in combination with other antibodies, all of which make them difficult to detect.

A

Kidd antibodies

7
Q

Made in response to pregnancy or transfusion

A

Kidd antibodies

8
Q

More frequently encountered Kidd antibody

A

Anti Jka

9
Q

Enzyme treatment of Kidd antibodies

A

Enhanced by LISS, PEG, increased Ab:Ag ratio

10
Q

Cause of Delayed Hemolytic Transfusion Reaction

A

Secondary/ Anamnestic Immune Response

11
Q

Increased bilirubin
Hemosiderinuria
DAT positive
Unexplained depletion of Hgb and Hct

A

Delayed Hemolytic Transfusion Reaction

12
Q

Urea transporter

A

Kidd glycoprotein

13
Q

Jka/Jkb is located at what position?

A

280

14
Q

Most abundant Kidd blood among Polynesian

A

Null phenotype

15
Q

Elute anti-Jk3, anti-Jka indicating that genes are expressed but only VERY WEAK

A

Dominant type Jk(a-b-)

16
Q

IgG
Phenotype as Jk(a-b-)
React optimally at IAT
ENZYME ENHANCED
HTR: Yes ( severe immediate and delayed)
HDN: Yes (mild)

A

Anti-Jk3

17
Q

Bacteria that were able to convert Jk(b-) cells to Jk(b+)

A

Enterococcus faecium and Micrococcus

18
Q

Bacteria that may have been the stimulus for an autoanti-Jkb

A

Proteus mirabilis