Kidney Nephrotic Nephritic Flashcards
(22 cards)
What is the immunofluorescence pattern associated with Good Pasteur’s syndrome?
Linear
Good Pasteur’s syndrome (RPGN)
What immunofluorescence pattern is seen in PSGN in children?
Granular IgG
PSGN (kids), Membranous (Elderly)
What immunofluorescence pattern is associated with Berger’s disease?
Granular IgA in mesangium
Berger’s disease
What is the immunofluorescence pattern seen in Lupus Nephritis?
Full house effect
Lupus Nephritis
What characterizes Pauci-immune conditions?
No deposits
Wegner’s, mPA (ca)
What are the symptoms of Nephritic Syndromes?
Inflammation present, hence Nephritic
Cola colored urine /dysmorphic RBCs/ RBC Casts / Hematuria / oliguria / hypertension
When does PSGN typically occur after pharyngitis?
10-21 days after pharyngitis
PSGN
What are the characteristics of PSGN?
Glomerular proliferation, Sub-epithelial humps
C3 and IgG on immunofluorescence
What is the immunofluorescence pattern seen in Berger’s Disease?
Mesangial proliferation, IgA in mesangium
Also known as IgA nephritis
What defines RPGN?
Cresentric glomeruli, Complication of PSGN (< 5%)
Usually immune-mediated (ANCAs, anti-GBM, ANA)
What are crescents in RPGN made up of?
Proliferated epithelial cells and WBCs
What characterizes Nephrotic Syndromes?
Proteinuria >3g/day, frothy urine
Destruction of GBM | Maltese cross in urine (also seen in Fabry’s disease)
What is Minimal Change Disease also known as?
Lipoid Nephrosis
No changes seen on light microscopy
What is seen in FSGS?
<50% of glomeruli affected
What are the types of Membranoproliferative Glomerulonephritis (MPGN)?
Type 1: Thick GBM, Hepatitis B/C
Tram track appearance; Type 2: Dense deposits
What is associated with Membranous Nephropathy in the elderly?
Adenocarcinoma (lung/colon) and melanoma
Antibodies against Phospholipase A2 receptors
What is the appearance of Membranous Nephropathy on electron microscopy?
Sub epithelial Spike and Dome
What is the first-line treatment for Steroid Resistant Nephrotic Syndrome (SRNS)?
Tacrolimus
What is seen in Kimmelsteil Wilson Disease?
Nodular Glomerulosclerosis
PAS (+) and seen in Diabetic nephropathy
What are the symptoms of Atheroembolic disease?
Fever + Rash + Allergic Intestinal Eosinophilia
Associated with Drugs, NSAIDs
Subepithelial deposits are seen in
PSGN MGN
Sub endothelial deposts
MPGN 1 wire loop lesions
