Vasc Events Of Inflammation Flashcards
(21 cards)
What is margination in the context of neutrophils?
Neutrophils come to the margin of blood vessels and exhibit rolling and weak adhesion
Which molecules mediate the rolling and adhesion of neutrophils?
Selectins (E/P/L selectins)
What is ICAM?
A molecule that binds to B2 integrin and is involved in leukocyte adhesion
What is the role of B2 integrin?
It binds to ICAM-1 and is important for leukocyte adhesion
What are the types of selectins and their corresponding cells?
- E-selectin - Endothelial cells
- P-selectin - Platelets, Endothelial cells
- L-selectin - Leukocytes
What do P-selectin and E-selectin bind to?
They bind to Sialyl Lewis X
What does L-selectin bind to?
Glycam, Madcam, and CD34
What is the function of integrins in leukocyte adhesion?
They mediate adhesion through binding to VCAM and ICAM
Which integrin is also known as VLA?
B1 integrin
What is the role of matrix metalloproteinase (MMP) in transmigration?
It breaks down the basement membrane and requires zinc
What mediates the process of transmigration or diapedesis?
PECAM-1/CD31
What is chemotaxis?
Unidirectional movement of white blood cells towards bacteria
What are the types of chemotactic agents?
- Exogenous: Bacterial Products
- Endogenous: LIC, LTB4, IL-8, C5a
What is opsonization?
The process of coating bacteria to enhance phagocytosis
What is the most important opsonin?
IgG
Which complement proteins are involved in opsonization?
- C3b
- C4b
- C5b
What is the most important complement opsonin?
C3b
What is phagocytosis?
The process of engulfing and digesting pathogens
What is oxygen-dependent killing in phagocytosis?
A more potent method of killing pathogens involving the H2O2-MPO-halide system
What enzyme is essential for oxygen-dependent killing?
NADPH oxidase
Fill in the blank: _______ is required for the function of matrix metalloproteinase.
Zinc
