Kirks Flashcards
(53 cards)
Nadir of neutropenia
1) most chemotherapeutic
2) carboplatin
3) lomustine
1) 5-10 days
2) 7-14 days (dogs) and 7-21 days (cats)
3) 7-28 days
Which chemotherapeutic can results in cardiac toxicity?
Doxorubicin
- acute: arrhythmia (via increased histamine and catecholamines)
- cumulative: decreased contractility
Which drug to give before doxorubicin to decrease toxicity?
Dexrazoxane
Both for cardiac or extravasation
Which chemo can results in urinary signs ?
Sterile hemorrhagic cystitis with Acrotelin
- cyclophosphamide
- ifosfamide
Which drug to decrease sterile hemorrhagic cystitis?
Furosemide with cyclophosphamide
Mesna with ifosfamide
Which chemotherapeutic is hepatotoxic?
Lomustine
Vésicant chemotherapeutic?
1) Vincrinstine/vinblastine/vinorelbine
Warm compress and DMSO
2) doxorubicin
Cold compress
Cat specificity with chemo drug ?
- Doxorubicin = cumulative nephrotoxicity
- Cisplatin = fatal pulmonary edema
- 5-fluorouracil = fatal neurotoxicity
Ideal diet content for patient with cancer?
High proteins + fat Low carbohydrate (provides energy to tumor)
Order of most common oral cancer in dogs ?
Melanoma, SCC, fibrosarcoma, peripheral odontogenic fibroma
Immunotherapy for oral neoplasia?
Xenogenic plasmid DNA vaccine
Chemotherapy for oral melanoma?
Carboplatin
Where are the apocrine glands of anal sac located ?
Within the stroma that lies between internal and external sphincter
Chemotherapy for perianal adenocarcinoma ?
Doxorubicin and platinum
Disease free interval for perianal adenocarcinoma of less than 5 cm with surgery?
2 years
AGASACA
Breed ?
Cocker
AGASACA : chemotherapy
Carboplatin
+/- mitoxantrone
Palladia
TCC metastasis sites?
LN, lung, liver, spleen
Pathogenesis of TCC:
1) Drugs
2) gender
3) breeds
- Old flea control, herbicides, cyclophosphamide
- obese females
- Scottish-terrier, WHWT, shetland, beagle, wirehaired terrier
TCC treatment options ?
Piroxicam
Mitoxantrone
Intravesical mitomycin
Risks factors for mammary cancers?
Spay older
Medroxyprogesterone
Obesity at young age
Most common mammary gland involved in dogs ?
Caudal
Negative prognostic factors
Ulceration, invasive, older, German Shepherd, large(>3 cm), male,
Chemotherapy for cats with mammary carcinoma?
Doxorubicin, cyclophosphamide, mitoxantrone
