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Flashcards in Krebs cycle Deck (9)
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1
Q

things we need to add?

A
water to first
to all dehydrogensase
NADH + H+ --> NAD+
NADH + H+ --> NAD+
FADH2 --> FAD
NADH + H+ --> NAD+
2
Q

8 reactions

A
condensation
isomerisation
decarboxylation
oxidative decarboxylation
substrate level phosphorylation
dehydrogenation
hydration 
dehydrogenation
3
Q

importance of condensation reaction

A

thioester bond cleaved; hence v exergonic

4
Q

importance of isomerisation

A

endergonic, but high conc of citrate drives it forward

5
Q

importance of oxidative decarboxylation

A

enzyme - alpha-ketoglutarate dehydrgonase complex - is homologous to pyruvate dehydrogenase, but different substrate specificity

6
Q

importance of substrate level phosphorulation

A

thioester bond cleaved; v exergonic so drives GTP formation

GDP GTP delta G=0

7
Q

importance of dehydrogenation

A

succinate dehydrogenase embedded in inner mito memb and has covalently attached FAD for entry of eelectrons into it

8
Q

importance of hydration

A

malonate is a structural analogue of succinate so can hinibit it

9
Q

importance of dehydrogenation

A

v endergonic but driven forward by low oxalocatetate conc

oxaloacetate conc kept low by endergonic citrate fromation