Kruse Flashcards
Somatic NS uses what NT and what receptor
ACh
nAChR
Location of nAChR - Unique
Adrenal Medulla (Nn)
Function of nAChR (ionotropic)
1) Excitatory
2) Release of Catecholamines
Agonists for nAChR receptors
ACh
Nicotine
Location of mAChR (metabotropic) - Unique
Sweat Glands
Function of mAChR
1) Excitatory and Inhibitory
2) Sweat Secretion
Agonist for mAChR
Acetylcholine
Muscarine
Which Muscarinic Receptors use Gi and which use Gq
M1,3,5 - Gq
M2,4 - Gi
Where does Dopamine synthesis occur
Cytoplasm
What is Dopamine synthesized from
Tyrosine
Where does Epinephrine and Norepinephrine synthesis occur
Vesicle
Conversion from NE to Epi occurs in where
Adrenal Medulla
How is Tyrosine transported into the nerve terminal for synthesis for other NTs
Na+-dependent tyrosine transporter
How is NE, Epi, DA, and serotonin transported into vesicles
Vesicular Monoamine Transporter (VMAT-2)
How is NE and DA reuptake into the nerve terminal
1) NE Transporter (NET
2) DAT
What is the fate of catecholamine after they are reuptaken?
Stored in vesicles via VMAT-2
List the two main enzymes that breakdown Catecholamines
1) Monoamine Oxidase (MAO)
2) Catechol-O- methyltransferase (COMT)
Rule of thumb B2 receptors Function
Relax smooth muscle - vasodilation
Rule of thumb for alpha-1 receptors
Smooth muscle contraction and vasoconstriction
Muscarinic receptor Rule of Thumb Function
Contract Smooth Muscle
Alpha 1 receptors use G___
Gq
A2 Receptors use G__
Gi
All the Beta Receptors use G___
Gs
Since Parasymp. dont innervate smooth muscle on vasculature, how can they influence vasodialtion.
1) Innervates Endothelium
2) Endothelium release NO
3) Vasodilation of SM
