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Pharm Test 3 > L 18 DRUGS anti coagulants > Flashcards

L 18 DRUGS anti coagulants Flashcards

(47 cards)

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1
Q

Aspirin (ASA) MOA?

A

Low dose:
sel. (-) TX A2 synthesis

High dose:
inhibit prostacyclin production and DEC efficacy of ASA

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2
Q

What is the antiplatelet drug of choice?

A

Aspirin

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3
Q

Aspirin SE?

A

inc hemorrhagic stroke

GI bleed

tinnitus

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4
Q

Aspirin contraindications?

A

children with viral illness

-> reyes syndrome

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5
Q

Clopidogrel MOA?

A

irreversible (-) P2Y12

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6
Q

Clopidogrel therapeutic uses?

A

Dec:
stroke

MI

unstable angina

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7
Q

Clopidogrel SE?

A

bleeding

TTP

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8
Q

Ticlopidine MOA?

A

irreversible (-) P2Y12

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9
Q

Ticlopidine therapeutic uses?

A

standard practice in combo w/ ASA

prevent stent thrombosis

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10
Q

Ticlopidine SE?

A

N/V
Diarrhea
Bleed

Neutropenia

TTP

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11
Q

Abciximab MOA?

A

Fab fragment of antibody targeting GP2b/3a

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12
Q

Epitifibatide MOA?

A

peptide (-) of fibrinogen binding site of GP2b/3a

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13
Q

Dipyridamole MOA?

A

(-) thrombus formation
(-) PDE
(-) adenosine uptake

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14
Q

Dipyridamole therapeutic use?

A

CV ischemia

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15
Q

Dabigatran Etexilate MOA?

A

direct thrombin (-)

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16
Q

Dabigatran Etexilate therapeutic use?

A

dec stroke in pt w/ atrial fib
DVT
Pul Embolism

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17
Q

Dabigatran Etexilate benefits?

A

less pt monitoring

equal to warfarin

rapid onset

less SE

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18
Q

Dabigatran Etexilate SE?

A

bleed

heartburn

stomach

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19
Q

Hirudin MOA?

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A

irreversible thrombin (-)

20
Q

Hirudin therapeutic uses?

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A

thrombosis

bc heparin induced thrombocytopenia

21
Q

Argatroban MOA?

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A

reversible thrombin (-)

22
Q

Argatroban therapeutic uses?

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A

pt w/ or at risk of heparin induced thrombocytopenia

23
Q

Bivalirudin MOA?

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A

reversible thrombin (-)

24
Q

Bivalirudin therapeutic use?

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A

coronary angioplasty

25
HMW Heparin MOA?
(-) 9a, 10a, thrombin by INC Antithrombin 3
26
How to administer HMW heparin?
IV or SC i.m = cause hematomas
27
HMW Heparin SE?
Heparin induced thrombo.
28
How to Tx OD of HMW Heparin?
Protamine Sulfate
29
LMW Heparin MOA?
(-) 10a by ANTITHROMBIN
30
LMW Heparin therapeutic use?
venous thromboembolism thrombosis pul. embolism unstable angina
31
LMW Heparin Advantages?
Longer 1/2 life 1 daily SC injections Dec thrombocytopenia, osteoporosis Less pt monitoring
32
Fondaparinux MOA?
(-) 10a by antithrombin only
33
Fondaparinux therapeutic uses?
venous thromboembolism thrombosis pul embolism
34
Fondaparinux advantages?
longer 1/2 life 1x daily SC Dec thrombocytopenia, osteoporosis Dec pt monitoring
35
Rivaroxaban MOA?
(-) 10a indirectly (-) maturation of Thrombin
36
Rovaroxaban advantage over Warfarin?
no titration
37
Rivaroxaban therapeutic uses?
venous thromboembolism after knee/ hip replacement DVT Dec thrombosis in pt w/ Fib
38
Warfarin MOA?
(-) Vit K epokide reductase lower Vit K recycling slow maturation of prothrombin, 7, 9, 10
39
Warfarin therapeutic uses?
Acute DVT Pul Embolism Venous thromboembolism Acute MI Prosthetic heart valve Chronic Afib
40
Warfarin SE?
crosses the placenta developmental defects hemorrhage
41
What is used to reverse Warfarin?
Phytonadione (Vit K)
42
What drugs INC Warfarin potency?
Aspirin Vit K def. Anabolic Steroid Antibiotics Tamoxifen Oral Hypoglycemics
43
What drugs DEC Warfarin potency?
alcohol oral BC corticosteroids barbiturates Inc Vit K Cholestyramine Green Veggies
44
Streptokinase therapeutic use?
I.v. ASAP after heart attack to dissolve clots
45
tPA MOA?
activates plasminogen bound to fibrin
46
tPA therapeutic use?
lysing thrombi for tx MI
47
What are tPA derivatives?
Reteplase -- less clot specific Tenecteplasen-- clot specific

Pharm Test 3 (8 decks)

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