L 19 Antipsychotic Flashcards
(25 cards)
What are the 3 classes of 1st generation Antipsychotics?
Phenothiazines
Butyrophenones
Thioxanthenes
What are the 4 classes of the 2nd generation Antipsychotics?
Dibenzodiazepines
Benzisoxazoles
Misc. Heterocyclics
Partial DA agonists
Neuroleptic Syndrome includes effects such as?
sedation
emotional quieting
psychomotor slowing
affective indifference
Aliphatics MOA?
low affinity D2 antagonists
Piperdines MOA?
higher affinity for D2 (than aliphatics)
Piperazines MOA?
high affinity D2 antagonist
What drugs are the least sedating of the D2 Antagonists?
Piperazines
1st Generation Butyrophenones MOA?
high to intermediate affinity for D2
Inc risk of extrapyramidal SE
What drugs are Butyrophenones?
Droperidol
Haloperidol
Droperidol SE?
prolong QT
Torsades
2nd Generation advantages?
weakly antidopaminergic
Dec tardives, parkinsonism
Clozapine therapeutic uses?
pt with negative antipsychotic symptoms
Clozapine SE?
agranulocytosis
myocarditis
cardiomyopathy
What needs to be monitored for a pt taking Clozapine?
troponin
cardiomyopathy
Olanzapine SE?
sleep walking
Benzisoxazoles MOA?
selective serotonin type 2A antagonists
At higher doses have Haloperidol effects
Lurasidone MOA?
activity at several 5HT receptors involved in learning and memory
lacks anticholinergic effects
Paliperidone MOA?
primary active metabolite of resperidone
antagonize D2 & SE
Asenapine therapeutic use?
adults with schizo
manic or mixed episodes Bipolar 1 w/ or w/out psychotic features
Pimozide therapeutic use?
severe tics
involuntary vocalization w/ Tourettes
What drug is a partial agonist?
Aripiprazole
Aripiprazole Therapeutic uses?
reduce:
neurolepsis
parkinsonism
tardive
that occur with the D2 antagonists
Aliphatics risk?
autonomic SE
Piperdines risk?
quinidine effects on heart
