L05 - Retina 2 Photoreceptors Flashcards Preview

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Flashcards in L05 - Retina 2 Photoreceptors Deck (6)
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1

CASE STUDY: JOAN
Age: 45 yo female
-Has trouble seeing at night
-Many car accidents
-Can read ok

What is her problem? Treatment?
-Black substance around eye
- Pigment under retina migrated into retina

Retinitis pigmentosa - genetic defect in rhodopsin or proteins involved in phototransduction. Tunnel vision (hence decrease in rods, explaining her poor night vision). No treatment yet but has pre clinical model using electrodes under retina to stimulate neurons in retina

2

Describe outer segment of photoR

Jar of coins (discs) having photopigment in between

3

What does inner segment of photoR contain?

Mitochondria, golgi

4

RPE function

-Supply photoR with vitamin A
-Absorb stray light, making it heavily pigmented

5

List from low to high wavelength of pigmented opsins

Blue, Rod, Green, Red
*Red and green cones have little difference in amino acid sequence
*Blue and green cones have MAJOR diff in amino acid sequence

6

_ retinal is in the middle of the___ , light converts it into ____ retinal

11-cis retinal, opsin, All-trans retinal