Flashcards in L01 & 02 - Introduction to basic concepts in systems neuroscience Deck (12)
Visual cortex can differ by ___% in individuals
Where are nociceptors found in the brain?
At the base of the brain and along major blood vessels - if you avoid those, you can cut through the brain or stimulate it without inflicting pain on the subject
Primary visual cortex aka _, area_, striate _____
V1, area 17, striate cortex
Lashley was searching for?
the engram - memory storage
*He trained animals to run mazes then lesioned different parts of brain. He re-run maze test 10 days later.
Lashley's 2 main findings in his search for the engram?
1) LARGE cortical lesions worked to destroy memory retention
2) SITE of lesion not important
Lasheley's 2 principles from his studies? What theory do they support?
1) Principle of MASS ACTION - memories stored diffusely throughout cortex
2) Principle of EQUIPOTENTIALITY - all parts of cortex play an equal role in memory storage
Support distributed theory
Franz Josepf Gall - distributed or localised theory of brain function?
LOCALISED, phrenology (shape and size of cranium), each area of head has a specific mental function
Nature of our perceptions depends on the nerves stimulated and NOT on the actual stimulus present - led to he idea of 1 to 1 mapping of end organs to parts of the brain (e.g. eye goes to one part of the brain, nerves from foot go to another)
The search for primary sites of epileptic seizures - discovered that the cortex is somatotopic
*Somatotopy is the point-for-point correspondence of an area of the body to a specific point on the central nervous system. Typically, the area of the body corresponds to a point on the primary somatosensory cortex (postcentral gyrus).
LTP occurs when?
EPSP first (pre), AP second (post)
!How does LTP occur?
*First there is depol. of NMDA R to remove Mg 2+ block then Glu binds leading to Na+ and Ca2+ influx
1) Ca2+ enters NMDA R
2) Ca2+ release from intracell. stores
3) Activation of CaCam Kinase II
4) Phosphorylate AMPA (increase conductance)
5) Silent channels also activated
6) Retrograde messenger leads to enhanced transmiter release