L10. mycobacteria

Question 1

…

Answer 1

…

Question 2

what is the target cell to infect for mycobacteria?

Answer 2

in alveolar macrophages

Question 3

what is the moa of mycobacteria?

Answer 3

teh response to mycobacteria by immune system causes the disease

Question 4

how do we refer to mycobacteria that does NOT cause TB?

Answer 4

Atypical mycobacteria/ MOTT…

Question 5

how doe we refer to mycobacteria that cause leprosy??

Answer 5

xx

Question 6

what is the most common infection caused by mycobacteria?

Answer 6

TB

Question 7

what is the second most caused infection by mycobacteria>

Answer 7

leprosy..

Question 8

what are the four groups of NT - MOTT? (runyon classification)

Answer 8

1.slow growing …
2.
3.
4.

Question 9

what is the prevalence of mycobacteria infection?

Answer 9

one third of the population

Question 10

….

Answer 10

….

Question 11

what is the difference b/w infection and disease?

Answer 11

infection - not necessarily disease

Question 12

how is TB transmitted?

Answer 12

aerosol transmission: after sneezing the mycobacteria stay in “clouds” of air

Question 13

droplet vs aerosol transmission

Answer 13

droplet -

aerosol -

Question 14

what is the pathogenesis of pulmonary TB?

Answer 14

intracellular multiplication - alveolar …macrophages

Question 15

what is caseation?

Answer 15

cheese in lungs…

Question 16

what is the most common cause of addisons diseaase?

Answer 16

x

Question 17

what is pott’s disease?

Answer 17

x

Question 18

what is skin TB?

Answer 18

lupus….

Question 19

x

Answer 19

IL 12 tnf alpha inf gammma

Question 20

3 characteristics of tb??

Answer 20

langhans giant cells, caseous granulomas, epthilod…???

Question 21

primary infection of tb called?

Answer 21

ghons focus

Question 22

does ghons focus mean disease?

Answer 22

no?

Question 23

x

Answer 23

night sweats, …

Question 24

what are the x

Answer 24

tuberculin skin test and ifn gamma - exposre tessts

Question 25

what are the disease Tb tests?

Answer 25

micrscopy and culture

Question 26

What is tuberculin (PPD) skin test - TST

Answer 26

x

Question 27

what is induration?

Answer 27

hard swelling

Question 28

what is IGRA?

Answer 28

interferon gamma release assay

Question 29

what are the antigens used for igra? (2)

Answer 29

esat - 6, cfp - 10

Question 30

TST vs IGRA? (3)

Answer 30

x

Question 31

what is a common urine contaminant during urine test (usually in men)?

Answer 31

mycobactera smegmatis...

Question 32

what is auramine stain>?

Answer 32

x

Question 33

what is cord factor?

Answer 33

mark of virulent mTB

Question 34

skip lab diagnosis

Answer 34

x

Question 35

what media is required to grow TB?

Answer 35

L -J media

Question 36

whatis the apperance of TB on l - j media?

Answer 36

rought tough...

Question 37

...

Answer 37

....

Question 38

what are the challeneges of treatment (apart from non compliace?) (2)

Answer 38

x mdr ...

Question 39

what are the four drugs of TB?

Answer 39

isonia...

Question 40

pan susceptible

Answer 40

tb is suceptible to all four drugs...

Question 41

group A b C drugs?

Answer 41

x

Question 42

...

Answer 42

....

Question 43

what is DOT?

Answer 43

directly observed therapy - WHOs strategy to eradicate TB

Question 44

...

Answer 44

....

Question 45

what is leprosy?

Answer 45

...

Question 46

...

Answer 46

...

Question 47

what are the two different types of leprosys? (2)

Answer 47

x

Question 48

can you culture m. leprae?

Answer 48

no

Question 49

what is z - n smear?

Answer 49

...

Question 50

what is leonine facies

Answer 50

x

Question 51

m. avium and intercellular..

Answer 51

x

Question 52

what is MAC? what are the diesease caused ? (3)

Answer 52

x