L11: Adrenergic Pharmacology

Question 1

Amphetamine-like indirect sympathomimetics (MOA, use, AE)

Answer 1

MOA: displaces stored catecholamines = NE release

Use:
-Hypotension
-Nasal decongestants
-CNS effects

AE:
-Cardio: increase HR/BP, arrhythmias
-CNS: paranoia, insomnia, HA, nervous

Question 2

Sympathomimetic drugs: Endogenous catecholamines (epi/ne) (MOA, use, AE)

Answer 2

MOA:
-NE: agonist at alpha and B1
-EPI: agonist at alpha, B1, B2

Use:
-Cardio: severe hypotension/shock, maintain BP
-Anaphylaxis: allergic rxn

AE:
-Arrhythmias
-Hypertension

Question 3

Sympathomimetic drugs: Nonselective a-agonists and a1-agonists (MOA, use, AE)

Answer 3

MOA: stimulate a1 and a2 receptors

HHHNOM

Use: (a1 effects only)
-Hypotension
-Nasal decongestants
-Ocular irritation
-Mydriatic agent for eye exams

AE:
-Hypertension
-Rebound hyperemia

Question 4

Sympathomimetic drugs: Nonselective b-agonists and b1-agonists (MOA, use, AE)

Answer 4

MOA: Stimulate B1 and B2 receptors

AABC, T

Use: (B1 effects only)
-AV block
-Bradycardia
-Acute heart failure
-Cardiogenic shock

AE:
-Tachycardia, other arrhythmias

Question 5

Sympathomimetic drugs: Selective B2 agonists (MOA, use, AE)

Answer 5

MOA: stimulate B2 receptors
-“terol”

Use:
-Asthma/COPD

AE:
-Tremor
-Tachycardia, arrhythmias

Question 6

Sympatholytic drugs: Nonselective a-antagonists and selective a1- antagonists (MOA, use, AE)

Answer 6

MOA: competitive antagonism at alpha receptors
-“osins”

PHORB

Use:
-Pheochromocytoma
-Hypertension
-BPH

AE:
-Orthostatic hypotension
-Reflex tachycardia

Question 7

Sympatholytic drugs: alpha2 agonists (MOA, use, AE)

Answer 7

MOA: stimulates a2 receptors

Use:
-Hypertension

AE:
-Sedation
-Dry mouth

Question 8

Sympatholytic drugs: Beta antagonists and B1 antagonists (MOA, use, AE)

Answer 8

MOA: competitive antagonists at beta receptors
-“lols”

HHAAAM, BBB

Use: (B1 effects only)
-Cardio: hypertension, angina, arrhythmias, heart failure, MI, (anxiety)

AE:
-Bradycardia, AV block
-Bronchoconstriction

Question 9

ACCRONYM TO REMEMBER

Answer 9

HAPH

alpha agonist : HHHNOM

beta agonist: AABC,T

alpha antagonist: PHORB

beta antagonist: HHAAAM, BBB