L79 - Random Qs about Hormone drugs Flashcards Preview

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Flashcards in L79 - Random Qs about Hormone drugs Deck (15):
1

How do OC pills work/ mechanism of action? 

E - suppressed mid-cycle LH surge and ovulation

P - changes endometrium to secretory to prevent implantation AND P increases cervical mucus to block sperm 

2

OC use and CAncer - cancers that they cause and cancers that they reduce? 

BENIGN LIVER TUMORS!!!! RISK

 

Reduced indicence of endometrial and ovarian cancer! 

3

What are the forms of Progesterone only OC? 

LARC

Depoprovera

Nexplanon

Skyle

Mirena

 

4

What are clinical uses for Progestins? 

Endometriosis and endometrial cancer

breast cancer

Premature births - Makena

5

What are estrogen uses? 

start puberty

pregnancy

cancer treatment

used as OC

6

What is Mifepristone and how does it work? 

Binds to Progesterone receptors 

Direct action on endometrium to cause shdeeding in 1-3 days (sensitizes to PG) 

Inhibits GH receptors in high concentrations 

7

the good and the bad of HRT

Alleviates acute menopausal symptoms like hot flashes and prevents osteoporosis

 

BUT

 

increases risk of CVD and cancer

8

What is used for infertility? / Ovulation induction? 

Clomiphene - Anti-estrogen used to increased LH/FSH for ovulation

 

 

9

What is tamoxiffen used for? 

Treatment of ER+ BC 

reduces contralateral tumors w/ fewer side efects

 

EStrogenic in uterus/endometrium and antiestrogenic in breast 

+estrogenic in bones and CV

10

Adverse effects of androgen use? 

stimulation of "latent" prostatic neoplasm in elderly 

retards growth in children and virilization of females

 

High Doses:

- Liver Tox

- Fluid retention --> CHF

-Renal Failure

 

11

Endocrine therapy for prostate cancer? 

Castration

high dose estrogens and anti-androgens 

Progerstone

LHRH analogs

12

Androgen Antagonists for Prostate Cancer Treatment

Flutamide and casodex and Abiraterone

13

What classes of durgs do you use for infertility? 

Antiestrogens and Aromatase inhibitors

14

What classes of drugs do you use for Breast Cancer? 

Antiestrogens

Aromatase inhibitors

15

What do you use to treat BPH? What do you use to terat prostate cancer? 

BPH - 5lpahreductase Finasteride

Prostate Cancer - antiandrogens and synthesisi inhibitors