How do OC pills work/ mechanism of action?
E - suppressed mid-cycle LH surge and ovulation
P - changes endometrium to secretory to prevent implantation AND P increases cervical mucus to block sperm
OC use and CAncer - cancers that they cause and cancers that they reduce?
BENIGN LIVER TUMORS!!!! RISK
Reduced indicence of endometrial and ovarian cancer!
What are the forms of Progesterone only OC?
What are clinical uses for Progestins?
Endometriosis and endometrial cancer
Premature births - Makena
What are estrogen uses?
used as OC
What is Mifepristone and how does it work?
Binds to Progesterone receptors
Direct action on endometrium to cause shdeeding in 1-3 days (sensitizes to PG)
Inhibits GH receptors in high concentrations
the good and the bad of HRT
Alleviates acute menopausal symptoms like hot flashes and prevents osteoporosis
increases risk of CVD and cancer
What is used for infertility? / Ovulation induction?
Clomiphene - Anti-estrogen used to increased LH/FSH for ovulation
What is tamoxiffen used for?
Treatment of ER+ BC
reduces contralateral tumors w/ fewer side efects
EStrogenic in uterus/endometrium and antiestrogenic in breast
+estrogenic in bones and CV
Adverse effects of androgen use?
stimulation of "latent" prostatic neoplasm in elderly
retards growth in children and virilization of females
- Liver Tox
- Fluid retention --> CHF
Endocrine therapy for prostate cancer?
high dose estrogens and anti-androgens
Androgen Antagonists for Prostate Cancer Treatment
Flutamide and casodex and Abiraterone
What classes of durgs do you use for infertility?
Antiestrogens and Aromatase inhibitors
What classes of drugs do you use for Breast Cancer?
What do you use to treat BPH? What do you use to terat prostate cancer?
BPH - 5lpahreductase Finasteride
Prostate Cancer - antiandrogens and synthesisi inhibitors