Lab 5: Flashcards
(17 cards)
What takes over in chronic inflammation?
macrophages and fibroblasts
IL-1 mediates
Fever
IL-2 stimulates
T cells
IL-3 stimulates
bone marrow
IL-4 stimulates
IgE production
IL-5 stimulates
IgA production
IL-6 stimulates
aKute-phase protein production
IL-8
major chemotactic for neutrophils
IL-12
Induces differentiation of T cells into Th1 cells. Activates NK cells
TNF-alpha
Mediates septic shock. Activates endothelium. Causes WBC recruitment, vascular leak
What are the chemotactic factors for neutrophils?
C5a IL-8 LTB4 Kallikrein \+ Bacterial breakdown products (Pathoma) \+ f-met-leu-phe
What are WBC casts in the urine characteristic of?
acute pyelonephritis
Pathogenesis of hematogenous acute pyelonephritis
septicemia/bacteremia
endocarditis
Pathogenesis of ascending acute pyelonephritis
Obstruction
Vesicoureteral reflux
Intrarenal reflux
What is the most common presentation of diverticulitis?
Left Lower Quadrant pain
Blood in the stool
Fever
Elevated WBC count
What does prostaglandin do in the stomach?
Increases mucous and bicarbonate production
Inhibits stomach acid secretion
Increase blood flow within the stomach wall
How does H. pylori contribute to PUD?
- LPS induces potent inflammatory and immune responses
- Increased gastric acid production
- Decreased duodenal bicarb production
