Lab 6 Flashcards
(34 cards)
C1 esterase inhibitor deficiency
CAuses hereditary angioedema due to unregulated activation of kallikrein - increased bradykinin, ACE inhibitors are contraindicated.
C3 deficiency
Increases risk of severe, recurrent pyogenic sinus and respiratory tract infections; increased susceptibility to type III hypersensitivity reactions.
C5-C9 Deficiencies
Terminal complement deficiency increases susceptibility to recurrent Neisseria bacteremia.
What do steroids inhibit?
Phospholipases
What do COX inhibit?
Cyclooxygenase
What does PGI2 cause?
Causes vasodilation, inhibits platelet aggregation
What does TXA2 cause?
Causes vasoconstriction, promotes platelet aggregation
What do PGD2, PGE2 and PGF2 do?
Vasodilation, potentiate edema
What do LXA4 and LXB4 do?
Vasodilation. Inhibit neutrophil chemotaxis. Stimulate monocyte adhesion.
What do LTC4, LTD4, LTE4 do?
Vasoconstriction, bronchospasm, increased permeability.
What does LTB4 do?
Chemotaxis for neutrophils
Which chemicals cause microbicidal actions?
ROS, NO, lysosomal enzymes
What chemicals cause pathologic inflammation?
IL-1, IL-12, IL-23, chemokines
What chemicals cause anti-inflammatory effects?
IL-10, TGF-Beta
What chemicals cause would repair and fibrosis?
Arginase, proline, polyaminases, TGF-Beta
What are the three ways that H. pylori causes acute gastritis?
- LPS induces inflammatory response
- Increased gastric acid production
- Decreased duodenal bicarbonate production
Acute Endocarditis: Type of bug
Staph aureus (high virulence)
Acute Endocarditis: Type of vegetations
Large vegetations
Acute Endocarditis: Type of valves
Previously normal valves
Acute Endocarditis: Onset
Rapid onset
Acute Endocarditis: Timeline
Occurs within days
Acute Endocarditis: Associated with?
IV drug use
Acute Endocarditis: which side of the heart?
Typically right-sided heart valves
Subacute Endocarditis: Type of bug
Strep viridans (low virulence)
