Learning and Memory Flashcards

1
Q

What is learning?

A

an attempt to create a memory that lasts

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2
Q

What is memory?

A

how you encode, store, and retrieve information

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3
Q

What is an engram?

A

the physical basis of memory - a pathway of cells/memory trace

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4
Q

How are memories established?

A

the formation of neuronal interconnections, susceptible to change

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5
Q

Distinguish between anterograde amnesia and retrograde amnesia

A

Anterograde - failure to store memories after trauma

Retrograde - failure to recall memories before trauma

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6
Q

What are the 3 stages of memory?

A
  1. Encoding
  2. Storage
  3. Retrieval
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7
Q

What is plasticity?

A

the brain’s ability to adjust its structure to reflect life’s experiences

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8
Q

Describe the process of neurogenesis (4)

A
  1. nerve cells form more synapses
  2. blood capillaries increase in the brain
  3. glial cells increase in size and number
  4. myelin sheath increases
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9
Q

Define neurogenesis

A

the process by which new neurons are formed in the brain

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10
Q

How does learning occur according to Pavlov and Skinner? (2)

A

Pavlov - classical conditioning (involuntary responses)

Skinner - operant conditioning (voluntary responses)

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11
Q

Describe classical conditioning (2)

A

conditioned stimulus is paired with an unconditioned stimulus to produce an unconditioned response

after several pairings, the conditioned stimulus alone produces a conditioned response

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12
Q

Describe operant conditioning

A

Responses are followed by reinforcement or punishment to strengthen or weaken behaviour respectively

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13
Q

Distinguish between positive and negative reinforcement, and punishment (3)

A

Positive - addition of positive stimuli to strengthen a behaviour

Negative - removal of negative stimuli to strengthen a behaviour

Punishment - addition of negative stimuli to weaken a behaviour

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14
Q

What was Lashley’s 1st hypothesis? (2)
Was it true or false?

A

learning depends on new/strengthened connections between 2 brain areas

hence, a cut somewhere in the brain interrupts that connection and destroys the learned response

Result: false

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15
Q

What was Lashley’s 2nd hypothesis? (2)

Was it true or false? Explain

A

certain portions of the cerebral cortex are more important than other for learning

hence, removing chunks of the cerebral cortex impairs learning

Result: false
Explanation: amount of tissue removed mattered, not from where it was removed

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16
Q

What did Lashley’s studies conclude? (2)

A

Learning and memory do not depend only on connections

Learning doesn’t depend only on one area

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17
Q

Explain Lashley’s principle of equipotentiality? (3)

A

all parts of the cortex contribute equally to learning

hence one part of the cortex can take over the function of another part

therefore, to destroy 1 function, the whole area must be destroyed

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18
Q

Explain Lashley’s principle of mass action (2)

A

the cortex works as a whole

hence if cortical tissue is destroyed after learning a complex task, deterioration of performance is determined by the amount of tissue destroyed

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19
Q

Where is engram found according to Thompson?

A

in the lateral interpositus nucleus of the cerebellum

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20
Q

Explain Thompson’s experiment regarding the LIP (3)

A

Classical conditioning:
tone (CS) + airpuff (UCS) –> eyeblink (UCR)

learnt response:
tone (CS) –> eyeblink (CR)

Pathway taken to the LIP:
facial nucleus –> red nucleus –> LIP

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21
Q

What results did Thompson’s experiment yield? (2)

A

Temporary inactivation of LIP blocked learning completely

Temporary inactivation of red nucleus blocked learning only during inactivation

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22
Q

What are the 3 types of memory?

A

Short term memory
Working memory
Long term memory

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23
Q

Define working memory

A

memory for temporary information required for carrying out cognitive tasks (e.g., learning)

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24
Q

What are the 2 types of long term memory?

A

Declarative (explicit) memory
Procedural (implicit) memory

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25
What are the 2 types of declarative memory?
Episodic memory Semantic memory
26
What are the 2 types of procedural memory?
Skills Habits
27
Describe episodic memory
autobiographical memories - things that have happened to you
28
Describe semantic memory
the conscious recollection of factual information and general knowledge
29
Describe procedural memory Give an example
memory of skills and procedures that can be used without conscious thought e.g., playing an instrument
30
What is the hippocampus responsible for? (4)
formation of long term declarative memories, especially episodic memories spatial memory context association memory consolidation
31
What are 2 properties of the hippocampus?
located in medial temporal lobe shaped like a seahorse
32
What 2 regions is the hippocampus made up of?
Dentate gyrus Cornu ammonis
33
What results from the removal of the hippocampus? (3)
moderate retrograde amnesia severe anterograde amnesia better procedural/implicit memory than declarative/explicit memory
34
Which brain structures are associated with procedural (implicit) (3) and declarative (explicit) memory?
Procedural: amygdala, medial temporal lobe, basal ganglia Declarative: hippocampus
35
Compare the learning functions of the basal ganglia and the hippocampus (2)
Basal ganglia: produces habits learns on reinforcement/punishment Hippocampus: produces flexible responses learns through making connections
36
What is the hippocampus's role in context association?
binding information to context by synchronizing the many brain areas a memory is spread across
37
What is the hippocampus's role in memory consolidation
guides the reorganization of information stored in the neocortex, so that it becomes independent of the hippocampus
38
What are 2 types of brain damage that result in amnesia?
Korsakoff's syndrome Alzheimer's disease
39
What is Korsakoff's syndrome caused by? (2)
Thiamine deficiency Chronic alcohol consumption
40
Distinguish between Wernicke's encephalopathy and Korsakoff's syndrome
Wernicke's encephalopathy - reversible Korsakoff's syndrome - non-reversible
41
How does Korsakoff's syndrome lead to amnesia?
the brain needs thiamine to metabolize glucose - without thiamine, there is decreased energy, leading to loss or shrinkage of brain neurons
42
Which brain area is most affected by Korsakoff's syndrome?
thalamus
43
What are symptoms of of Korsakoff's syndrome? (5)
apathy retrograde amnesia anterograde amnesia ataxic gait (cerebellar dysfunction) confabulation
44
What is confabulation?
wild guessing mixed with correct information to hide memory gaps
45
Distinguish between dementia and Alzheimer's (2)
Dementia - umbrella term Alzheimer's - disease that falls under dementia Therefore, not every type of dementia is Alzheimer's, but every case of Alzheimer's is dementia
46
Describe the 3 stages of Alzheimer's? (9)
Mild - getting lost, taking longer to complete daily tasks, repeating questions Moderate - problems recognizing family, inability to learn new things, paranoia Severe - cannot communicate, bedridden, dependent on others
47
What is found in the brain of people with Alzheimer's? (3)
amyloid plaques (outside neurons) neurofibrillary tangles (inside neurons) broken neural connections
48
What causes amyloid plaques and neurofibrillary tangles?
Amyloid plaques: accumulation of amyloid beta protein 42 Neurofibrillary tangles: altered tau function - destabilization of microtubules
49
What is the treatment for Alzheimer's? (2)
Donepezil - inhibits acetylcholinesterase - prevents breakdown of acetylcholine Memantine - blocks NMDA receptors - prevents Calcification
50
Explain the hypothesis of synaptic plasticity (2)
when we learn something, we create specific physical changes in our brain these changes are modifications of synaptic connections and strength - making synapses more efficient
51
Explain the Hebbian Synapse mechanism (2)
neuron A repeatedly excites neuron B - causing a growth process to take place in one/both cells as a result neuron A is then more able to excite neuron B
52
Define habituation
a decrease in response to a stimulus that is presented REPEATEDLY and accompanied by NO CHANGE in other stimuli
53
Describe habituation in an aplysia (2)
the aplysia's siphon is stimulated, causing the sensory neuron to release normal amounts of neurotransmitter when habituation occurs, the release of neurotransmitter by the sensory neuron decreases
54
Define sensitization
an increase in response to a mild stimulus as a result of EXPOSURE to a more INTENSE stimulus
55
Describe sensitization in an aplysia
a strong stimulus on an aplysia's skin intensifies a later withdrawal response to touch
56
What is long term potentiation? (LTP) What does it depend on? (3)
the major cellular mechanism that moves memories into long term storage changes at synapses long lasting enhancement of synaptic strength modification in signal transmission
57
What changes does LTP involve? (2)
physical change in neuron structure strengthening of neural connections
58
How does LTP occur? (2)
1. one or more axons bombard a dendrite with stimulation 2. the burst of stimulation leaves the synapse potentiated for a period of time - making the neuron more responsive for minutes/days/weeks
59
What are 3 properties of LTP? Explain them.
Specificity - only active synapses are strengthened Cooperativity - simultaneous stimulation by 2 or more axons produces LTP more strongly than repeated stimulation by 1 axon Associativity - pairing weak input with strong input enhances later responses to weak input
60
What do the biochemical mechanisms of LTP depend on?
changes at glutamate synapses - involving AMPA and NMDA receptors
61
What type of receptors are AMPA and NMDA?
Ionotropic - allows ions into postsynaptic neuron when stimulated
62
Describe the process of LTP (4)
1. repeated glutamate excitation of AMPA receptors strongly depolarizes the membrane 2. depolarization removes Mg ions blocking NMDA receptors - allowing glutamate to excite them 3. Ca ions enter the neuron, triggering the activation of the protein CaMK2 4. More AMPA receptors are built and dendritic branching increases - resulting in increased responsiveness to glutamate
63
What occurs when CaMK2 is activated? (3)
1. CaMK2 sets in motion a series of reactions resulting in the release of another protein: CREB 2. CREB goes to the nucleus of cell regulating gene expression 3. CaMK2 and CREB propagate into the dendrites, triggering the release of BDNF
64
What are the functions of BDNF (3)?
prevents cell death induces neurogenesis maintains neurons' survival
65
What changes occur in the presynaptic neuron after LTP? (2)
1. postsynaptic neuron releases retrograde neurotransmitter - which gets absorbed by the presynaptic neuron 2. retrograde neurotransmitter modifies and regulates neurotransmission - creating a stronger link between neurons
66
What is long term depression? (LTD)
processes selectively weaken specific sets of synapses in order to make synaptic strengthening useful - occurs after LTP