Lec 04- General Sensory Mechanisms II Flashcards

(63 cards)

1
Q

What makes up the primary somatosensory area?

A

Brodmann’s area 1,2,3

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2
Q

What makes up the somatosensory association area?

A

Brodmann’s area 5, 7

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3
Q

What are the results of widespread bilateral excision of somatosensory area I?

A

Loss of ability to:

  • Localize discretely the different sensations in different parts of the body (crude localization still possible)
  • Judge critical degrees of pressure against the body
  • Judge weights of objects
  • Judge shapes or forms (asterognosis)
  • Judge texture of materials

**Pain and temperature sense = still preserved but poorly localized

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4
Q

Where does the somatosensory area II receive signals from?

A
  • Brain stem (transmitted upward from the body bilaterally)
  • Secondarily from somatosensory area II
  • Other sensory areas of the body (visual and auditory)
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5
Q

What is required for function of somatosensory area II?

A

Projections from somatosensory area I

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6
Q

What does the removal of somatosensory area II do to the neurons in somatosensory area I?

A

Removing II has no apparent effect on response of neurons in I

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7
Q

Which layers of the somatosensory cortex receive input signals from lower brain centers?

A

1

2

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8
Q

Which layer of the somatosensory cortex has large neurons in it that project to distant areas such as basal nuclei, brainstem, and spinal cord?

A

5

6

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9
Q

Which layers of the somatosensory cortex send information through corpus callosum to the opposite hemisphere?

A

2

3

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10
Q

Which layer of the somatosensory cortex has its axons project to the thalamus?

A

6

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11
Q

How are receptor potentials created?

A

By opening modality gated channels (Na+ channels) that are opened in response to membrane deformation caused by the touch or pressure

Touch/pressure > membrane deformation > Na+ channel opens > receptor potential

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12
Q

if the receptor potential is strong enough (through summation), it may generate an AP at the _______________ on the primary sensory neuron

A

1st node of Ranvier

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13
Q

Where do the primary sensory neurons originate from?

A

from peripheral receptors

Merkel’s receptors

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14
Q

Through which roots of the spinal nerves do the primary sensory neurons enter the spinal cord?

A

dorsal roots

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15
Q

Where are the cell bodies of the primary sensory neurons located?

A

dorsal root ganglia

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16
Q

Where do the primary sensory neurons synapse?

A

in spinal cord with secondary neurons

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17
Q

Where do the secondary sensory neurons originate from?

A

spinal cord gray matter

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18
Q

Where do the secondary sensory neurons travel through?

A

myelinated columns of the spinal cord

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19
Q

Do the secondary sensory neurons decussate?

A

YES

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20
Q

Where do the secondary sensory neurons synapse?

A

thalamus with tertiary neurons

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21
Q

Where do the tertiary sensory neurons travel through?

A

internal capsule

Myelinated pathway between thalamus and some of the basal nuclei

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22
Q

Where do the tertiary sensory neurons synapse?

A

somatosensory cortex

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23
Q

Where does two-point discrimination touch travel?

A

dorsal column-medial lemniscal pathway

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24
Q

What is two-point discrimination touch?

A

the ability to distinguish 2 separate points as close as 2mm apart

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25
Why is lateral inhibition important?
- Blocks the lateral spread of excitatory signals | - Increases the degree of contrast in the cerebral cortex
26
What are the 3 synaptic levels where lateral inhibition occurs?
- Dorsal column nuclei - Ventrobasal nuclei of thalamus - Somatosensory cortex
27
Dorsal column-medial lemniscal pathway through the CNS
1- Primary neurons (peripheral sensory neurons) originate from receptors in periphery 2- Travel through a spinal nerve 3- Travel through dorsal root of respective spinal nerve 4- Continue into spinal cord 5- Travel up spinal cord through dorsal columns 6- Axons in fasciculus gracilis synapse in lower medulla in nucleus gracilis 7- Axons in fasciculus cuneatus synapse in lower medulla in nucleus cuneatus 8- Secondary neurons travel through brain stem as paired tracts (medial lemniscus) 9-Secondary neurons synapse in basolateral nucleus of thalamus with tertiary neurons 10- Tertiary neurons travel through internal capsule to somatosensory cortex
28
Where do the axons from the lower limbs travel though in the dorsal column-medial lemniscal pathway?
in the medial portions of the 2 dorsal columns Fasciculus gracilis
29
Where do the axons from the upper limbs travel through in the dorsal column-medial lemniscal pathway?
in the lateral portions of the 2 dorsal columns Fasciculus cuneatus
30
What are free nerve endings?
pain receptors (nociceptors)
31
What are the 5 characteristics of fast pain?
- Felt within 0.1 seconds after stimulus - Not felt in deeper tissues - Elicited by mechanical and thermal stimuli - Carried by Ad pain fibers - Pain fibers terminate in lamina I (lamina marginalis) of dorsal horns of spinal cord
32
Which pain fibers are myelinated?
alpha (fast pain)
33
Which pain fibers are non-myelinated?
C fibers (slow pain)
34
What are the 4 characteristics of slow pain?
- 1 second after stimulus and increases over several seconds - Aching, slow burning, throbbing, nauseous, chronic - Elicited by mechanical, thermal, chemical stimuli - Carried by C type fibers - Pain fibers terminate in layers II and III (Substantia gelatinosa) of dorsal horns of spinal cord
35
Pain pathway
1- Pain travels through Anterolateral pathways 2- Primary pain fibers synapse in dorsal horns (Layers I, II, or III) with secondary fibers 3- Secondary fibers immediately decussate (make up Anterolateral pathways) 4- Fast pain fibers synapse terminate in Ventrobasal nuclei of thalamus (make up Neospinothalamic tracts) 5- Tertiary fibers ascend to somatosensory cortex
36
What do the fast pain fibers make up?
Neospinothalamic tracts
37
What do the secondary pain fibers make up?
Anterolateral pathways
38
What do the slow pain fibers make up?
Paleospinothalamic pathway
39
Where do most of the paleospinothalamic secondary fibers terminate?
throughout the brainstem (some pass all the way to the thalamus)
40
What is the nt for the Ad fibers of the fast pain pathway?
glutamate
41
What do the Type C fibers or slow pain release?
- Glutamate (acts instantaneously) | - Substance P (released slowly)
42
When does Brown-Sequard Syndrome occur?
hemisection of the spinal cord
43
What happens to the motor function in Brown-Sequard Syndrome?
Blocked on side of the transection in all segments BELOW the level of the transection
44
What is lost on the OPPOSITE side of the transection in Brown-Sequard Syndrome?
- sensations of pain, heat, and cold (spinothalamic pathway) - in dermatomes 2-6 segments BELOW the level of transection
45
What is lost on the SAME side of the transection in Brown-Sequard Syndrome?
- kinesthetic and position sensations - vibration sensations - discrete localization - two-point discrimination -in ALL dermatomes BELOW the level of transection
46
What are the 3 components of the Analgesia system?
- Periaquaductal gray & Periventricular regions of brainstem and 3rd ventricle - Raphe magnus nucleus & Reticular nuclei in medulla - Pain inhibitory complex in dorsal horns of spinal cord
47
What are the reticular nuclei?
regions of gray matter in the middle of the brainstem
48
What are the 3 types of receptors that discriminate thermal gradations?
- cold - warmth - pain
49
What are the warmth nerve endings?
-free nerve endings
50
What types of fibers are the warmth nerve endings mainly transmitted over?
Type C fibers
51
How many more cold receptors are there than warm nerve receptors?
3-10 times as many
52
What type of endings are the cold receptors?
- Small - Type Ad - Myelinated
53
What stimulates cold and warmth receptors?
changes in their metabolic rates
54
Thermal signals are transmitted in pathways ___________ to those for pain signals
parallel
55
When does referred pain occur?
when visceral pain fibers are stimulated and stimulate some of the pain fibers that conduct pain signals from the skin
56
When does severe pain result?
diffuse stimulation of pain nerve endings throughout the viscera (opposed to highly localized types of damage to the viscera)
57
What does the diffuse pain result in?
ischemia
58
What type of fibers are all visceral pain from the thoracic and abdominal cavities transmitted?
Type C pain fibers
59
What are headaches a result of?
referred pain to the surface of the head from deep head structures
60
What is almost completely insensitive to pain?
the brain
61
What kinds of injuries and conditions can result in headache?
-
62
What is the difference between headaches caused by meningitis, migraines, and removal of CSF?
-
63
What are the 3 areas of headache?
- Nasal sinus and eye HA - Cerebral vault HA - Brainstem and Cerebellar vault HA