Lec 1

Question 1

6 components of local solution

Answer 1

LA agent
Vasoconstrictor
Reducing agent
Preservative
Fungicidal and bacteriostatic agent
Vehicle

Question 2

All la are

Answer 2

Amhipathic

Question 3

Structurally la have

Answer 3

Lipophiloc aromatic ring connected to a hydrophilic group by intermediate chain

Question 4

Intermediate chain can be

Answer 4

Amide or ester

Question 5

Esters of Benzoic acid

Answer 5

Cocaine

Question 6

Esters of paraaminobenzoic acid

Answer 6

Procaine

Question 7

Amides are used than esters

Answer 7

More

Question 8

Amides are

Answer 8

Articaine
Lidocaine
Mepivacaine
Prilocaine

Question 9

If a patient has liver problems you cannot use

Answer 9

Amides

Question 10

If local anesthetic as 2 I in its name its a

Answer 10

Amide

Question 11

Most common la in dentistry is

Answer 11

Lidocaine

Question 12

Lidocaine belongs to a

Answer 12

Amide class- a littl allergenic reaction hypoallergenic. Sets on quickly produce desired anesthesia effect for several hours

Question 13

Lidocaine metabolised in

Answer 13

Liver by microsomal fixed function oxidases

Question 14

Half life of lidocaine is

Answer 14

90 minutes

Question 15

Mrd of lidocaine is w epinephrine

Answer 15

7mg\kg body weight w epinephrine not to exceed 500 mg

Question 16

Mrd without epinephrine is

Answer 16

4.4mg\kg not to exceed 300mg.

Question 17

Mepivacie is a

Answer 17

Rapid acting amide LA
Onset time longer wout vasoconstrictor non allergenic

Question 18

Mrd of mepivvacaine is

Answer 18

6.6mg\kg not to exceed 400 mg

Question 19

Most commonly used mepivacaine % is

Answer 19

3% wout vasoconstrictor

Question 20

Prilocaine is _________ than lidocaine

Answer 20

Less toxic
It’s an amide
Onset of action slow

Question 21

Mrd of Prilocaine is

Answer 21

8mg\kg with max 600 mg

Question 22

Prilocaine is contraindicated in

Answer 22

Idiopathic congenital methemoglobinemia
Hemoglobinopathies
(Sickle cell anemia)
Anemia
Cardiac, respiratory failure induced by hypoxia

Question 23

A hybrid molecule classified as amide is

Answer 23

Articainne

Question 24

Articaine is metabolised in

Answer 24

Liver and plasma
Metabolised faster

Question 25

Articaine is contrainidicated in person with

Answer 25

Sensitivity to amide type La Sulfite sensitivity person (some asthmatic patient with allergic type asthma)

Question 26

Bupivacaine is ____ time potent than lidocaine

Answer 26

$ times potent than lidocaine mepivacaine Prilocaine 4 times less than lidocaine and mepivacaine Vasodilator activity greater than lidocaine Prilocaine mepivacaine

Question 27

Why do we not use bupivacaine a lot ?

Answer 27

Duration is too long 9 hours Slower onset time than la Irritating to tissue can case pain Can be used in management of post surgical pain cancer patient

Question 28

Factors in selecting LA

Answer 28

Length of Time of pain control necessary Potential need for post treatment control Requirement for hemostasis Presence of any contraindications (absolute or relative) to local anesthetic solution selected for administration. Patient allergies liver failure don’t use amide

Question 29

Las are chemicals that reversibly block

Answer 29

Action potentials in cell excitable membranes