Lec 1: Innate vs. Adaptive immunity Flashcards
(20 cards)
What are 3 attributes of Innate Immunity
Born with it, Need it to Live, Non-specific
What are the cells involved in innate immunity?
From less to more specific: pluripotent stem cell, myeloid progenitor, mast, myeloblast, basophil, neutrophil, eosinophil, monocytes, macrophages, dendritic cells
What are the 3 attributes of adaptive immunity?
develops over time (not born with it), can live without it, specific
What are the cells involved in adaptive immunity?
from less to more specific: lymphoid progenitor cell, natural killer cells (increased by drumming, singing in group), T cells and CD4/CD8 (T cells) and B cells and plasma cells (with antibodies- Y)
ANTIGEN
protein or substance that is not you, gets concentrated in lymph nodes
when exposed to an antigen, what happens?
they get concentrated in the lymph node
MACROPHAGE
“big eater”, eats foreign substances and carries to lymph node, puts some of it onto its own membrane to be recognized by T cells
T-CELLS
CD4 AND CD8, specific for one pathogen, circulate, going from lymph node to lymph node looking for true love (i.e. the foreign substance they are specific for), when it finds foreign substance, it will: 1)make cytokines 2) kill the infected cell 3) or go searching for more infected cells
CYTOKINE
hormone of the immune system
ALLOSTASIS
mount an immune response, sustain it, then go back to normal
DEFENSIN
INNATE IMMUNE SYSTEM
anti-microbial peptide found on skin and mucosa and in granules of neutrophils, attack cell wall of bacteria (have affinity for negatively charged phospholipids)
keep flora in gut from overflowing
can act as CHEMOKINE (cytokine that causes movement)
lack of them implicated in excema and Crohn’s disease
increase # with Vitamin D
KININ
ADAPTIVE, ACUTE PHASE PROTEIN, activated when physical barrier crossed, made in liver, stored until injured, responsible for itching and pain/nerve stimulation, results in MOVING CELLS INTO INJURED TISSUE (via smooth muscle contraction and striated muscle relaxation)
OPSINIZE
INNATE, like frosting
coats microbe to make easier to consume/digest
ORGANS OF THE IMMUNE SYSTEM?
skin, gut, bone marrow, spleen, lymph node, blood
physical immune barriers
skin/membrane, mucus, cilia, tear/saliva/sweat
CHEMOKINE
cytokine that causes movement, defensins can act as chemokines
lysozyme
innate, physical, in saliva, enzyme that chops foreign particles up
CRP
"COMPLEMENT REACTIVE PROTEIN" ADAPTIVE OPSINIZES FOREIGN SUBSTANCE activates complement protein measured when testing for inflammation increase in CRP means more likely to get alzheimers, diabetes, heart disease
COMPLEMENT
proteins that poke holes in bacteria (an other cells if not kept in check), CRP is example
SURFACTANTS IN LUNG
physical barrier, innate, opsinize foreign particles
