Lec 11 - HIV Infection Flashcards
which cells do HIV virus target mainly
cd4 T cells
3 phases of hiv/aids
acute
asymptomatic
development of aids
initially, where are the most cd4 t cells lost
30-60%
lost in gut associated lymphoid tissue
what type of HIV virus predominates early on
CCR5
why does virus become more ehterogenous during asymptomatic phase
Virus population becomes more heterogeneous due to accumulated mutations
rate that CD4 cells reduce at in asymptomatic/ year
60,00/ml/year
where does virus replicate during asymptomatic phase
continues in lymph nodes and lymphatic tissue
(dendritic cells will also interact with virus, but virus cant replicate in these)
where is the latent resovoir of virus
in quiescent memory t cells
definition of aids
<200 T cells/ml plasma
what type of HIV virus predominates during AIDS
CXCR4
name of idnividuals that never progress to aids
elite controllers
(rare)
what do dendritic cells do
Dendritic cells in mucosa bind HIV shed by macrophages and deliver it to CD4+ T cells in lymph nodes
what part of dendritic ccell binds to gp120
DC SIGN
4 steps of virus binding to on CD4 cell
- binds heparin sulfate
- GP120 binds to CDV4
= conformational change! - coreceptor binds CCR5
or
CVCR4 - fusion protein delivers viral capsid into cell
where does reverse transc occur
inside the capsid
