Lec 6 - Signal Transductance

Question 1

what does cyclic AMP phophodiesterase do?

Answer 1

breaks down cAMP to 5’-AMP (not an active second messenger)

Question 2

what is the B aadrenergic signaling cascade

Answer 2

use a GPCR -> Gs -> AC -> cAMP -> activated PKA

Question 3

How many cAMP per PkA?

Answer 3

4 cAMP for each PKA. 2 for each regulatory sub unit. releases 2 catalytic subuints

Question 4

Protein phosphorylation can stimulate or inhibit activity, or alter association with other proteins. t/f

Answer 4

true

Question 5

Proteins are phosphorylated on ____, ____, or _____ residues.

Answer 5

Serine/Threonine, or Tyrosine

Question 6

What reverses protien phosphorylation?

Answer 6

protien phosphatase

Question 7

4 examples of serine/threonine kinases

Answer 7

PKA
PKG
PKC (activated by DAG & Ca2+)
myosin light chain kinase (activated by Ca2+ & calmodulin)

Question 8

Example of tyrosine kinase

Answer 8

insulin receptor

Question 9

IP3 pathway

Question 10

ca2+ and calmodulin

Question 11

Gs
Gi
Gq