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Public Health (Virology) > Lect.1 > Flashcards

Lect.1 Flashcards

1
Q

are obligate intracellular parasite

A

Viruses

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2
Q

composed of only proteinaceous matter responsible for human disease

A

Prions

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3
Q

Sizes?

A

Parovirus- 20nm

Poxvirus- 300 nm

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4
Q

Viruses are described as ___ cz they pass through bacterial filters

A

filterable agents

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5
Q

Capsomeres are subunits that are

A

bound to covalent bonds to facilities release of genome during replication

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6
Q

____ found on the envelope of viruses can act as legends for virus or have certain activities

A

Spikes

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7
Q

enveloped viruses are sensitive to ether?

A
  • dissolves lipids present on envelope /lossing its ligand
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8
Q

Loss of envelope led to the loss of infectivity ?

A

Ligand present on surface is lost

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9
Q

Role of host in virus replication?

A

Acts as a factory, providing substrates, energy and machinery for synthesis of coat proteins and nucleic acid genomes

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10
Q

Steps of Virus Replication?

A
  • Recognition & Attachment to the target cells

-

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11
Q

Receptor recognition of HIV?

A

CD4 receptors of the T-helper cells

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12
Q

Receptor recognition of Enveloped Influenza virus?

A

Hemagglutinin

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13
Q

Viruses may prefer certain target tissue

A

Tropism

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14
Q

some viruses at neural PH promote cell-to-cell fusion ?

A

Syncytia

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15
Q

Examples of some viruses at neural PH promote cell-to-cell fusion ?

A

Measles Paramyxovirus, HIV

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16
Q

The virus is then delivered to the replication site

A

Uncoating

17
Q

DNA viruses replicate in the nucleus except:

A

Proxvirus

18
Q

RNA viruses replicates in the cytoplasm except :

A

Retroviruses

19
Q

penetration aka:

A

Viropexis

20
Q

The most important step in virus Replication

A

Synthesis of Macromols

21
Q

RNA virus must ______ during the stage of synthesis of Macromols

A

encode for enzymes which transcript the RNA

22
Q

What happens to DNA viruses during the stage of synthesis?

A

DNA Viruses replicate in the nucleus utilizing the cells DNA-dependent RNA polymeraze

23
Q

replication differs according to the ___

A

type of the nucleic acid core

24
Q

____ are released after cell lysis

A

Naked virus

25
Q

How are naked viruses released after cell lysis?

A

Budding

26
Q

How are viruses ( that acquire their envelope) in the cytoplasm released?

A

Require cell lyses before released

27
Q

The time interval after penetration and before assembly

A

Eclipse

28
Q

During the eclipse cycle, ______ could not be isolated

A

Infective Virion

Public Health (Virology) (2 decks)

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