Lecture 1 Flashcards
(53 cards)
Homeostasis
A Healthy Balance.
pH 7.4
Temp 34 degree C
Extracellular Fluid
-Underneath Skin and Between Cells
-Content of Cells Living Conditions
Intracellular Fluid
- Internal Environment of Cells
- Contents of the cell.
Homeostasis Lungs
-CO2 removal
-Acid/base buffer (temp)
Homeostasis GI System
-Nutrients and Volume
-Origins of ECF
-gets rid of waste
Homeostasis Kidney
-Tight Control of Electrolytes
-Acid/ Base Volumes
-Pressures in the Circulatory System
Homeostasis Liver
-Get rid of “bad”
-Using Chemical Runs to change the structure and natural waste
Homeostasis Peripheral Vascular Bed
-High Speed portion of ECF
-Blood Volume 5L/min
-CO 5L/min (rest)
-30-40 L/min with activity
Homeostasis Capillaries
-oxygen making its way out of tissues
-waste products going back into circulatory system; usually by diffusion
-diffusion is slower than pumping blood around circulatory system
Negative Feedback
The Process our body uses to control most of our functions
1.) Sensor
2.) Thinking/Integrate (Brainstem)
Negative Feedback Example (BP)
BP setpoint is 100. Barocreptors look at this pressure. BP increases, baroreceptors send that info to the nervous system. Nervous system will react to bring the BP back to 100.
Negative Feedback (Pulmonary)
CO2 increases. Body caused an increase in ventilation. Causing the CO2 to decrease.
Vicious Cycle
-Positive feedback gets in a vicious cycle until the death of a patient.
-When positive feedback goes wrong.
Positive Feed Back Definition
-Involves a change and amplification -of the change
-used less than negative feedback
Positive Feed Back Example (Good)
Oxytocin is released. Cervix stretches. Telling the brain to release more oxytocin. Continues until birth.
Positive Feed Back Going bad
-Blood Clotting Cascade that doesn’t terminate with control of bleeding
-Results in vessels clotting off
-Resulting in Heart attack d/t no perfusion
Positive Feedback:
Sepsis/Necrosis
-Cells unable to work b/c the environment around them in collapsing and not improving
Positive Feedback:
Severe Acidosis
-Depresses CNS, Causing more acidosis
-Depresses Respiratory Drive
Positive Feedback:
Peripheral Acidotic Conditions
-Decrease in percussion to the leg
-Body unable to clear the acidosis
-Causing healthy tissue to die
Positive Feedback:
Atheroscleric Plaque Clotting
-Coagulation Cascade union the point of no shutdown
Postive Feedback:
Diabetic Renal Inflammation/Hyperfiltration
Born with 200 million nephron. The more we age and lose nephrons, causing more work for other nephrons. Aging them faster.
Postive Feedback:
Sever Hemorrhage
Low BP, causes low CO. Aorta pressure low. Coronary blood vessels pressure low. Continuing and weakening the heart until heart failure.
Compensated Shock
-Negative Feedback works well
-You can lose 20% or 1 L of blood and the body will compensate, regenerate and return to normal over time.
Decompensated Shock
-Positive Feedback leads to death, negative feedback insufficient.
-Lose 20% or 2L of blood, the body can not compensate without assistance such as transfusion.
