Lecture 1 Flashcards

1
Q

What does the hypothalamus do

A

Maintains homeostasis

Body temperature, blood pressure, fluid and electrolyte balance, body weight

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2
Q

What does the nucleus of the solitary tract do

A

Collects sensory information from the vagus nerve and relay it to hypothalamus

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3
Q

What sort of sensory information does the nucleus of the solitary tract include

A

Blood pressure

Gut distension

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4
Q

What does reticular formation do

A

Nucleus in the bloodstream that recieves a variety of input from the spinal cord

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5
Q

What sort of information is linked with reticular formation

A

Skin temperature

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6
Q

Where is the hypothalamus

A

Below the thalamus and posterior to the optic chiasm

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7
Q

What is the retina

A

Fibres from the optic nerve go to a small nucleus in the hypothalamus

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8
Q

What is the nucleus called that the retina fibres go to

A

Suprachiasmatic nucleus

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9
Q

What does the suprachiasmatic nucleus do

A

Regulates circadian rhythms

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10
Q

Hat are the circumventricular organs

A

These nuclei are located along the ventricles

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11
Q

What is unique about the circumventricular nuclei

A

They lack the blood brain barrier

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12
Q

What does the limbic and olfactory system do

A

Help to regulate behaviours such as eating and reproduction

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13
Q

What do intrinsic receptors do

A

Monitor temperature and ionic balance

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14
Q

What are the 2 main outputs

A

Neural signals

Endocrone signals

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15
Q

Where do neural signals go

A

To the autonomic system

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16
Q

Where do the hypothalamus project too

A

Medulla

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17
Q

What can the hypothalamus control

A

Heart rate
Vasoconstriction
Digestion
Sweating

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18
Q

Where do endocrone signals travel too

A

Pituitary gland

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19
Q

Where in the hypothalamus send their axons to the pituitary gland

A

Third ventricle

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20
Q

Hypothalamus cells in the third ventricle send their axons to which pituitary gland

21
Q

What do the axon terminals release into the bloodstream

A

Oxytocin

Vasopressin

22
Q

Where do smaller cells send their axons

A

To the base of the pituitary

23
Q

Where do the smaller cells axons release hormones into

A

Capillary system of the anterior pituitary

24
Q

What can the hypothalamus change

A

Blood pressure
Body temperature
Metabolism
Adrenaline levels

25
What are the 2 pituitary glands called
Posterior pituitary | Anterior pituitary
26
What is adenohypophysis
Anterior pituitary
27
What is neurohypophysis
Posterior pituitary
28
What 3 cells types are in the adenohypophysis
Acidophils Basiphils Chromophobes
29
Is it true or false that the neurohypophysis is an extension of the hypothalamus
True
30
How are hormones released from the anterior pituitary gland
The hypothalamus secretes releasing hormones which stimulate hormones release in the pituitary
31
What are releasing factors
Releasing hormones that stimulate hormone release
32
What is it meant about true hormones
Secreted in the bloodstream and act at a distance
33
What is vasopressin thought to stimulate
ACTH secretion
34
What is CRH
Corticotropin releasing hormones
35
How many amino acids does CRH have
41 amino acids straight chain
36
What group is crucial for activity
Amide group
37
What is TRH
Thyrotropin releasing hormones
38
Hypothalamus secretes TRH causes what
Release of TSH from anterior pituitary
39
What is the only problem in secreting TRH
It can also cause the release of prolactin, growth hormone and MSH
40
Where is TRH produced
Medial neurons of the hypothalamus
41
What is GH
Growth hormone
42
How many amino acids is growth hormone
191
43
Name another hormone that is in GH family
Prolactin
44
How many amino acids does prolactin have
198
45
What is required for signal transduction of GH
Receptor dimerization
46
How many binding sites do GH have
2 GH receptor monomers to form a dimer in the plasma membrane
47
What will a dimerised GH receptor recruit
Cytoplasmic tyrosine kinase
48
By recruiting a cytoplasmic tyrosine kinase what does it do
Phosphorylates the GH receptor
49
What happens after phosphorylation
Signal transducers and activators of transcription are phosphorylated and moved to the nucleus