Lecture 1 Flashcards
T/F: Inner cell mass is NOT centrally located
True
What are the three stages of development of the neural tube?
Neural plate
Neural fold
Neural tube
Neural plate stage
Columnarization of epithelium (simple cuboidal to simple columnar)
Neural fold
Thickened neural plate folds along anterior-posterior axis to form the neural groove flanked by neural folds
Where does folding begin and then what folds next?
Folding begins in middle and continues cranially and caudally
Neural tube stage
Opposing edges of neural folds fuse along anter-post axis to form neural tube
Separates from the simple cuboidal epith
When does superior/cranial neuropore close?
Inferiors/caudal?
Cranial: Day 27
Caudal: Day 30
Tripartite brain components
Prosencephalon
Mesencephalon
Rhompencephalon
Please Meet Ron
Pentapartite brain components
Telencephalon (from Prosen) Diencephalon (from Prosen) Mesencephalon Metencephalon (from Rhomben) Myencephalon (from Rhomben)
Match ventricle/space with part of Pentapartit brain
Lateral ventricles Mesenceph
Third ventricle Telenceph
Fourth ventricle Metenceph
Cerebral aquaduct Myelenceph
Dienceph
Lateral ventricles - Telenceph
Third ventricle - Dienceph
Fourth ventricle - Metenceph/Myelenceph
Cerebral aquaduct - Mesenceph
Anencephaly
Failure of cranial end of neural tube to close
Missing forebrain
Not viable
Holoprosencephaly
Failure of prosencephalon to divide into two cerebral hemispheres
What facial deformaties are often associated with Holoprosencephaly
Single orbit with two eyes, one eye, or no eye
Proboscis-type nose located above eye
Cleft lip and palate
Not viable
Spina bifida occulta
Failure of caudal neuropore to close
Vertebral arch fails to form
Spinal cord function usually normal
Patient comes in with tufts of hair at caudal end of vertebral column and spinal cord function is normal. What does patients likely have?
Spinal bifida occulta
Patient comes in with cyst at caudal end of vertebral column, spinal cord function is impaired and lower extremity dysfunction. What does patients likely have?
Spina bifida cystica
Spina bifida cystica
Failure of caudal neuropore to close Sac-like cyst at caudal end of spine Spinal cord and/or meninges in cyst Spinal cord function may be impaired May have lower extremity dysfunction Bladder and bowel function may be impaired
Which form of SBC is characterized by each?
a. Failure of caudal neural folds to close; most severe defects
b. Only meninges found in sac; spinal cord function impaired
c. Both spinal cord and meninges found in sac; lower extremity paralysis, bowel and bladder dysfunction, loss of sensatrion to lower limbs
a. Myeloschisis
b. Meningocele
c. Meningomyelocele