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Flashcards in Lecture 1 Deck (26)
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1
Q

Epidermis Renewal

A

Biweekly by maturation and exfoliation. Fed from the dermis and subcutaneous circulation. Denucleation occurs.

2
Q

Dermis Renewal

A

Actively metabolizing tissue retains structure. Elastic fibers. Does not de-nucleate and exfoliate.

3
Q

Elastic fibers in dermis

A

elastin, collagens, GAGs (clycosaminoglycans/mucopolysaccharides)

4
Q

Epidermal cells

A

continually replicating and maturing into the cornified protective stratum corneum layer

5
Q

Dermal fibroblast cells

A

responsible for production and homeostasis of the underlying structural later of skin by synthesis and excretion of fibrillar proteins

6
Q

Melanocytes

A

production and transport of melanin inter- and intracellularly

7
Q

Langerhans cells

A

dendritic immunologic actors

8
Q

Hair follicle

A

produces complex hair structure in an orderly cycle from epidermal cells

9
Q

Sebaceous gland

A

holocrine excretory gland producing sebum for hair and skin lubrication. Exits into hair shaft.

10
Q

Eccrine sweat glands

A

secretory bodies that act to control internal temperature by secreting water while maintaining electrolyte balance.

11
Q

Apocrine glands

A

associated with hair follicles; secretes milky fluid which contains proteins and lipid. May have pheromonal function, impacts body odor.

12
Q

Nerve receptors

A

tactile, temperature, pressure, stimulus response.

13
Q

Merkel’s disk

A

touch, pressure (static)

14
Q

Meissner’s corpuscule

A

touch, pressure (dynamic)

15
Q

Ruffini Ending

A

stretching of skin

16
Q

Pacinian corpuscule

A

deep pressure, vibration (dynamic)

17
Q

Krause end bulb

A

Thermoreceptor

18
Q

Tan

A

increased production of melanosomes to melanocytes

19
Q

Production of dermis

A

fibroblasts

20
Q

Skin physiology

A

Processing of xenobiotics, immunological responses, and radiation responses

21
Q

Skin pharmacology activity

A

antioxidants, anti-inflammatory, enzyme modulation, immune enhancement

22
Q

Lipophilic zone

A

stratum corneum, viable epidermis. As SC keratonizes, it becomes more lipophilic to keep water in and toxins out

23
Q

Hydrophilic zone

A

dermis

24
Q

Routes of skin penetration

A

transfollicular, direct transdermal (Most common), via eccrine gland

25
Q

Desmosome

A

holds together corneocytes

26
Q

Skin penetration issues

A

active ingredients must pass through S.C., penetration depends on polarity of active charge and hydration of S.C.