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EXCI 259: PHYSIOLOGY > lecture 1: Guyton chapter 9 > Flashcards

lecture 1: Guyton chapter 9 Flashcards

1
Q

heart is apprx the size of your…

A

fist

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2
Q

what is the location of the heart

A

Superior surface of diaphragm
Left of the midline
Anterior to the vertebral column, posterior to the sternum

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3
Q

true or false: the left and ride side of the heart are the saem

A

false; they are anatomically and functuonaally seperate

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4
Q

what does it mean for the heart to be a dual pump

A

right=lungs

left=systemic

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5
Q

what ensures that the blood from the left and right side of the heart does not mix.

A

The interventricular septum

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6
Q

true or false: even if the left adn right sides are sperated, the heart contracts in a coordinated fahsion?

expalin

A

truwe

the atria contract together and the ventricles contract together….

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7
Q

the left side of the heart is coupled in///

A

parrallel

blood goes to diff capilaries depending on where its needed

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8
Q

the right side of the heart is coupled in …

A

series

only goes from heart lungs and back top heart

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9
Q

which side is a low pressure system

A

right sife

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10
Q

which side is a high opressure ssytem

A

left

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11
Q

why is the left side a high pressure system

A

mut overcome systemic pressure

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12
Q

explain the pathway of blood though the body

A

1) O2 deficient blood returns from body via sup and inf vena cava
2) enters right atrium
3) enters right ventricle
4) goes to puilmonary artery
5) goes to lungs

6) blood is oxygenated
=PULMONARY CIRC.

7) blood comes back through pulmonary veins
8) blood goes to left atrium
9) blood goes to left ventricle
10) blood goes to aorta

11) circulatets to the body
=systemic circualation

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13
Q

what is the lining that covres the heart

A

pericardium

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14
Q

what is the pericardium

A

a double walled sac around the heart

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15
Q

what are the 2 layers of pericardium

A

1) superficial fibrous pericardium

2) a deep 2 layer serous pericardium

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16
Q

what are the 2 layers of the deep serous periodcardium

A

parietal layer and vsiceral layer

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17
Q

where does the parietal layer line

A

the interal surface of the fibrous pericardium

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18
Q

where does the vsiceral layer line

A

lines the surface of the heart

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19
Q

what is another name for the visceral layer

A

the epicardium

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20
Q

what are the visceral and parietal layers serpated by

A

fluid filled pericardia cavity

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21
Q

what are the.3 fucntions of the pericardium

A

Protects and anchors the heart

Prevents overfilling of the heart with blood

Allows for the heart to work in a relatively friction-free environment

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22
Q

what allows Allows for the heart to work in a relatively friction-free environment

A

the pericardial space that is fluid filled

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23
Q

what are the 3 types of cardiac muscle

A 
atrial muscle (the chambers that receive the blood)
ventricle msucle (chambers that eject
special excitatory and conductive msucle fibers
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24
Q

what is the difference between cardiac and skeletal muscle cotnraction

A

Atrial and ventricular types of muscle contract in much the same way as skeletal muscle
However, the duration of contraction is much longer

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25
why is heart muscle contraction longer than sksetla msucle
heart needs time to fill after blood ejection
26
true or false: cardiac msucle is smooth
false its branched and striated
27
wher eis the nucleus of cardiac muscle
centrally located
28
what are muscle cells of the heart called
myocutes (cardiomyocytes) | or myofibrils
29
what is the outside membrane of the cardiac muscle caleld
sarcolemma
30
true ro false: Cardiac muscles have the same arrangement of actin and myosin, and the same bands, zones and Z discs as skeletal muscles forming sarcomeres.
true thats what make it straited
31
which has less sarcoplasmic reticulum: cardiac or skeletacl
cardiac
32
where does cardiac muscle get its calcium from and why
from extracellular flued for contraction (they have large t tubyles) beacuse lsss sarcoplasmic retulum
33
which has larger T tubule diamters: cardiac or sckeletal
cardiac (5 times greater diameter0
34
what does it mean for cardiac muscle to act as a syncytium
cardiomytocites are electrically connected to the next cell coordinated contraction of muscles along their entire length
35
true or false: Cardiac muscle fibers are made up of many individual cells connected in series
false | in series AND and in parallel with one another
36
explain intercalated disks
cell membranes separating and anchoring individual muscle cells from one another At each intercalated disc, the cell membranes have fused
37
at the intercalated disks, the cell mebranes are smoothe>
false | they are rough which allows for increased surface area
38
where is one cardiac cell connected to the other>
at the intercalated disk
39
what are the fucntions of gap junctions
Gap junctions allow almost free diffusion of ions | Action potentials travel easily from one cardiac muscle cell to the next
40
what hhelps speed the conductuon of AP in heart muscle
the syncitum of mant heart muscles
41
true or false: there is an atrial and ventricle syncytium?
true
42
explain atrial and ventricular syncytium
the atrial synscetim means taht the conduction only occurs and dioffuses through atrial cells simular to ventricualr
43
true or false, the atrium and ventricle are serpeated
true by a fibours tissue
44
why is it importance that there is a dual syncytium for atrium and ventircles
allows atrium to contract a bit before ventricles (ventricles will be relaxed while blood flows from cotracted atrium) to bill the heart with as much as possible)
45
what does This division of the muscle of the heart into two functional syncytiums allows
allows the atria to contract a short time ahead of ventricular contraction
46
what does the myocardium consist of
interlacing bundles of cardiac muscle fibers arranged spirally around the circumference of the heart.
47
what is the advantage of the bundles being spiral
the cardiac muscle contracts & shortens, a twisting effect is produced, efficiently pushing blood upwards towards the exit of the major arteries of the heart.
48
what is the AP in ventricular muscle fiber
-85 mV
49
after initial spike, the mebrane remains depolarixed for 0.2 s, what does that vcause?
platea
50
what does the prescens of this platea in the AP cause i nterms of ventricular contraction>
ventricular contraction to last as much as 15 times as long in cardiac muscle as in skeletal muscle
51
what are the 5 phases of action potenial in cardiac muscles
phase 0: membrane is depolarixe by fast NA channels and slow CA channel phase 1: K+ cahnnels open once the mebrane is positive =begining to repolarize phase 2: platuea occurs because efflux of K+=influx of ca+ phase 3: K+ channels open alow and membrane repolaises phase 4: resiting membrane potential
52
the cardiac cycle consists of
diastole and systole
53
what is diastole
of a period of relaxation (diastole) during which the heart fills with blood and the cardiomyocytes re-establish the Na+/K+/Ca2+ gradient
54
what is systole
contraction | ejects blood
55
what is each cardiac cycle initiated by
initiated by a spontaneous generation of an action potential in the sinus node =special excitatory cells depolarize by themsevles
56
the AP is conducted where
in the atria, the AV bundles and the venetcles
57
true or false: there is A delay of more than 0.1 sec during passage of the cardiac impulse from the atria to contract ahead of ventricular contraction
yes and that causes | Thus atria pump more blood into the ventricles prior to ejection
58
true or false: blood does not slow continually from vena cava to atria
false, blood flows continueally
59
what percentage of blood flows directly through the atrai into ventricels even before contraction
80%
60
atrial contraction causes an additional BLANK to fill the ventricles
20% filling of blood
61
what is the a wave caused by
pressure change in atria caused by atrial contraction
62
what is the c wave occur
occurs when ventricles begin to contact | pulls a bit on the atrium as well since they are attached so affects pressure
63
when does v wave occur
towards the end of venticular contraction | because as it relaxes, sicne it is attached to the atrium, it causes the pressure oin the atrium to change
64
true or false: walls of the atria ar ethicker than walls of the ventricles and why
false, ventrciles are thigcjer because they are ejecting blood
65
which wall is thicker: left or right ventrciel
left is thicker because it is a high pressure system
66
when does aortic pressure start to increase
during systole after the aortic valve opens
67
when does aortic pressure decrease
towards end of ejection pahse
68
what is the relationship between aortic pressure and ventricualr volume
as aortic pressure increases, ventricular volume decreases
69
after aortic valvule closes, what develops and why
incisura develops due to a sudden back-flow towards the left ventricle (pulse wave gets bounced off by systemic resistance
70
what does the insura supply
the back flow supplies the heart
71
wyy does aortic pressure start to decrease diuring diastole ?
elasticity of the aorta
72
why is it imporatnt to allways have some blood in the ventricles
1) makes it easier to refill for next cardiac cycle | 2) w/o blood, ventricle could colapse
73
explain why as voume is increase in the ventricle, pressure isnt increase in ventricle
heart is expanding
74
what is the end diastolic volume
when the heart is filled wiht blood | =preload
75
at a given volume, after the heart filled, what happens
isovolumic contraction (ie./ ventricle contracts, pressure is building,
76
during the period of ejection, is pressure constant ?
Almost constant but not really because the heart needs to contract against a lesser and lesser amount of blood
77
what is the end systolic volume
after load (all the blood has been ejected)
78
what happens after all the blood has been ejected
isolvolumic relaxtion, ventricles relax so pressure decrases
79
whast is ejectrion volume (stroke bvolume)
end diastole-end systolic
80
what is the ejection fraction
stroke volume/diastolic
81
what are normal ejection fraction values
50 - 60% at rest; > 80% during exercise and < 40% during disease
82
what is the frank starling mecaism
An intrinsic ability of the heart to adjust and adapt the volume change of blood
83
explain the frank starling emcanism
Within physiological limits the heart pumps all the blood that returns without excessive damming in the veins. Extra stretch on cardiac myocytes makes actin and myosin filaments find a more optimal degree for force generation. =ribber band effect forces blood out and not contractility
84
true or fasle: the heart only contract s sympatheic nerves
false, it has parasympathic nerves (mostly valgus nerve)
85
where is the parasympathetic nerves located
around the atrium
86
explain the function of the parasympathtic nerves
relaxes the heart rate (since cotnaction happens in atrium)
87
explain the sympathetic nerves
effects hr and contractility (how forceful)
88
excitation of the heart happens by what nerves
symphatetic nerves
89
what can the excitation of the hear tdo to the heart rate
go from 70 to 180-200
90
truw ro false: sympahtic nervers only effect the HR
false, Sympathetic stimulation also increases the force of heart contraction to as much as double, thereby increasing the volume of blood pumped.
91
Under normal conditions, sympathetic nerve fibers to the heart discharge BLANK at a slow rate which causes...
continouesly This maintains pumping at about 30% above ‘normal’ heart rate with no sympathetic stimulation
92
true ro false: Strong parasympathetic stimulation (PS) can stop the heart for a few seconds
true
93
at rest, what is responsible for beating rest
parasymptehtic
94
where are the vagal fibers mainly distributed
to the atria and not much to the ventricles (where power of contraction occurs

EXCI 259: PHYSIOLOGY (21 decks)

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