lecture 3: guyton chapter 11 Flashcards
what 2 types of nervous systems act on tthe pacemaker activity
sympathetic and parasymphathesic
explain 3 ways which the parasympatheic nevous system can affect pacemaker actibit
1) slower depolarzation (less sodium entering cells, slower HR)
2) lower resting membrane pottential (more energy needed to reach tthreshold)
=longer=slower HR
3) more positive threshold
longer to reacher=slower HR
true or false: ventricular cells have leaky sodium which allows them to have inherent excitatory abilityies
false, no leaky
need exact energy for thresholf
explain phase 0 of ventricular AP
depolarizing impoulse activates fast NA+ channels and inactivates K+ channels.
explain phase 1 of ventricular Ap
Transient opening of K+ channels and Na+ channels begin to close
(k+ starts to excit the cell)
explain oahse 2 of ventricular AP
Ca2+ channels are open, key difference between nerve AP.
balance between influx of calcium and efflux of K
what is the key difference between vetnricualr AP and muscle AP
calcium channels are open for a period of time while K+ channel are also open
explain phase 3 of AP ventricualr
: repolarization, Ca2+ inactivate and K+ channels open.
explain phase 4 of the ventricular AP
resting membrane potential near the K+ equilibrium potential.
(few leaky channels)
the resting potential of the heart is near the K+ equi, the Ca2+ or the NA+ equiblium
k+
where is AP generated
SA node
why is AP generated in SA node
;eaky cells
expalin the steps or cnduction in the heart
1) AP initiated in SA node
2) AP travels through atrical cells (they get depolzarizd easily through syncituim)
3) Signal gets colelcted at AV node and gets slowed down because of less gap junctions
4) signal passes through bundle of His to the ventricules
5) moves trhough purkingje fibers to the apex of the herat
6) signal moves inside to outside and upwards to facilate the emptiying during contraction
why and how the signal slowed down at the AV node
to allow the atrium to contract before the ventricels (max filling)
they have less gap junctions
why is the signal collected at the bundle of His
only place where the signal can travel through the fibrous memebrane between atrium to ventricle
what device is used to record the depolar and repolar wve>
voltmeter
if the depolzarTion wave moves towards the postive node, what type of reading on the volt meter
postive
if the repolzation wave moves towards the postive node, what type of reading on the volt meter
negative
the depolar and repolar wvaes move from the BLANK electrode to the B;LANK electrodide
neg to postive
true or false: when the cardiomyocyte is either completely depolarized or repolarized there is no potential recorded
true w
the mean vector through a partially depolazrised heart goes towards where
down towards the apex of the heart
what recrods the signal (negative or postivie)
postive node
what dpes bipolar lead mean
ECG is recorded from 2 electrodes on the body
expain where lead 1 is placed
The negative terminal of the electrocardiogram is connected to the right arm, and the positive terminal is connected to the left arm.