lecture 1 to 8 Flashcards

(23 cards)

1
Q

pharmacology

A

the study of how drugs affect the body and how the body affects drugs

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2
Q

what was the worlds first synthetic drug

A

salvarsan

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3
Q

three routes to create drugs

A

folk medicine ie the nautral product eg aspirin and cocaine
serendipity eg penicillin
synthetic chnemistry eg procian and salvarsan

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4
Q

pharmacodynamics

A

mechanism of drug action

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5
Q

pharamacokinetics

A

handling of the drug by the body

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6
Q

intracellular drug targets

A

nuclear hormone recptors and enzymes

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7
Q

extracellular drug targets

A

voltage gated ion channel tyrosine kinase repctor transporter enzyme ligand gated ion channel and g coupled protein repcptor

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8
Q

what are ligand gated channels named after

A

their activating ligand, not the ubstance they transport eg GABA a

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9
Q

pharmacognosy

A

study of drugs from nautral sources

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10
Q

ligand gated ion channels exaples

A

gaba type a receptor
nicotinic acetylcholine recptor
glycine recptor
ionotrpic glycine recptor

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11
Q

ligand gated channel strcutre

A

pentamer- five subunits 2 alpha 1 beta one delta and one epsilon
2 binding sites for acetylcholine
each subunit has 4 transmembrane domains, the second tmd forms the linning of the ion channel, contains hydrophilic amino acids
agonist bindig site located in large loop between TM3 and TM4

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12
Q

`strcutre of voltage gagted channel

A

larger alpha subunit and smmller beta subunit
aphasubunit has for pseudosubunits each containing 6 transmembrane domains
membrane dippin gdomians between tm5 and tm6 form lining of channel
tm4 is the voltage ensor

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13
Q

GPCRs

A

seven transmembrane domains
most diverse
muscarinic receptors
adrenergic receptors

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14
Q

affinity

A

how tightly something binds

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15
Q

kd

A

used to emasure affinity

is the dissociation constant , the concentration of drug that gives 50% the maximum occupancy

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16
Q

the higher the kd

A

rhe lower the affinity

17
Q

ec50

A

conc of drug giving 50% of the maximal effect

18
Q

pitency

A

the conc of drug required to give certain resonse

19
Q

competitive antagonisjm

A

surmountable
parallel curve to the right with no change in maximum response
reversible

20
Q

ic50

A

concentration of antagonist fiving 50% of the control response
changes with agonist concentration

21
Q

selectivity

A

is the rekative potency or sffinity at one receptor compared with another

22
Q

non competivie

A

reduces maximum effect]is unsurmoutable

23
Q

uncompetitive

A

use dependent