lecture 1 to 8 Flashcards Preview

drugs > lecture 1 to 8 > Flashcards

Flashcards in lecture 1 to 8 Deck (23)
Loading flashcards...
1

pharmacology

the study of how drugs affect the body and how the body affects drugs

2

what was the worlds first synthetic drug

salvarsan

3

three routes to create drugs

folk medicine ie the nautral product eg aspirin and cocaine
serendipity eg penicillin
synthetic chnemistry eg procian and salvarsan

4

pharmacodynamics

mechanism of drug action

5

pharamacokinetics

handling of the drug by the body

6

intracellular drug targets

nuclear hormone recptors and enzymes

7

extracellular drug targets

voltage gated ion channel tyrosine kinase repctor transporter enzyme ligand gated ion channel and g coupled protein repcptor

8

what are ligand gated channels named after

their activating ligand, not the ubstance they transport eg GABA a

9

pharmacognosy

study of drugs from nautral sources

10

ligand gated ion channels exaples

gaba type a receptor
nicotinic acetylcholine recptor
glycine recptor
ionotrpic glycine recptor

11

ligand gated channel strcutre

pentamer- five subunits 2 alpha 1 beta one delta and one epsilon
2 binding sites for acetylcholine
each subunit has 4 transmembrane domains, the second tmd forms the linning of the ion channel, contains hydrophilic amino acids
agonist bindig site located in large loop between TM3 and TM4

12

`strcutre of voltage gagted channel

larger alpha subunit and smmller beta subunit
aphasubunit has for pseudosubunits each containing 6 transmembrane domains
membrane dippin gdomians between tm5 and tm6 form lining of channel
tm4 is the voltage ensor

13

GPCRs

seven transmembrane domains
most diverse
muscarinic receptors
adrenergic receptors

14

affinity

how tightly something binds

15

kd

used to emasure affinity
is the dissociation constant , the concentration of drug that gives 50% the maximum occupancy

16

the higher the kd

rhe lower the affinity

17

ec50

conc of drug giving 50% of the maximal effect

18

pitency

the conc of drug required to give certain resonse

19

competitive antagonisjm

surmountable
parallel curve to the right with no change in maximum response
reversible

20

ic50

concentration of antagonist fiving 50% of the control response
changes with agonist concentration

21

selectivity

is the rekative potency or sffinity at one receptor compared with another

22

non competivie

reduces maximum effect]is unsurmoutable

23

uncompetitive

use dependent