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Genomics > Lecture 10 - Gene Mapping In Complex Diseases II > Flashcards

Lecture 10 - Gene Mapping In Complex Diseases II Flashcards

1
Q

Rheumatoid Arthritis Definition

A

Autoimmune Disease resulting in inflammation of tissue in joints
Unknown Cause

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2
Q

Epigenetics Definition

A

Study of inherited changes in phenotype caused by mechanisms other than changes in underlying DNA sequence

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3
Q

3 Types of Epigenetic Modifications

A

DNA Methylation
Histone Modification
Non-coding RNAs

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4
Q

DNA Methylation Features

A

Methylation of C5 of Cytosine
Uses DNA Methyl-transferase

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5
Q

Hypomethylation Definition

A

Overall Decease in DNA methylation

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6
Q

Hypermethylation Definition

A

Overall Increase in DNA Methylation

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7
Q

Environmental Factors affecting Epigenetics

A

Nutrition
Chemicals
Behavioural Factors
Reproductive Factors

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8
Q

Epigenetic Example in diabetes

A

Maternal nutrition in utero

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Genomics (9 decks)

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