Lecture 12: Memory & Amnesia Flashcards

1
Q

Multiple Memory Theory

A

the idea that we have a number of different kinds of memory, each of which is dependent on different neural structures

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2
Q

Anterograde Amnesia

A

inability to acquire new memories subsequent to a disturbance such as head injury, electroconvulsive shock, or certain degenerative diseases

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3
Q

Retrograde Amnesia

A

an inability to remember events that took place before the onset of amnesia

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4
Q

Time-Dependent Amnesia

A

amnesia that is typically induced by traumatic brain injury, the severity of which determines how far back in time the amnesia extends, from the present to the more-distant past and generally shrinking over time, often leaving a residual amnesia of only a few seconds to a minutes for events immediately preceding the injury

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5
Q

Childhood (Infantile) Amnesia

A

an inability to remember events from infancy or early childhood

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6
Q

Fugue State

A

a sudden, usually transient, memory loss of personal history accompanied by abrupt departure from home and assumption of a new identity

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7
Q

Explicit Memory

A

a memory in which a participant can retrieve an item and indicate that he or she knows the item (i.e. conscious memory)

conscious, intentional remembering of events, facts, and personal experiences (episodic memories) that depends on conceptually driven, top-down processing in which a person reorganizes the data to store it

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8
Q

Episodic (Autobiographical) Memory

A

memory of life experiences that is centered on the person him- or herself

a person’s recall of singular events that enables human beings to remember personal experiences

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9
Q

Autonoetic Awareness

A

awareness of one’s self, or self-knowledge

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10
Q

Uncinate Fasciculus

A

a fiber pathway connecting temporal and frontal cortices

a hooked or curved tract

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11
Q

Semantic Memory

A

a memory of world knowledge stored independently of the time and place at which it was acquired

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12
Q

Ammon’s Horn

A

a region of the hippocampal formation named for the mythological horn of plenty

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13
Q

Dentate Gyrus

A

the region of the hippocampal formation

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14
Q

Granule Cells

A

sensory cells of the hippocampus

neurons that are round in appearance

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15
Q

Perforant Pathway

A

a pathway that connects (“perforates”) the hippocampus to medical temporal (limbic) regions

when disrupted, results in major hippocampal dysfunction

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16
Q

Fimbria Fornix

A

a pathway that connects the hippocampus to the thalamus, prefrontal cortex, basil ganglia, and hypothalamus

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17
Q

Entorhinal Cortex

A

cortex on the medial surface of the temporal lobe that provides a major route for neocortical input to the hippocampal formation

often shows degeneration in Alzheimer disease

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18
Q

Implicit Memory

A

a nonconscious and nonintentional memory of learned skills, conditioned reactions, and events

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19
Q

Priming

A

an experimental technique that involves using a stimulus to sensitive the nervous system to a later presentation of the same or a similar stimulus

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20
Q

Depth-of-Processing Effect

A

an improvement in subsequent recall of an object that a person has given thought to (in terms of, e.g. its meaning or shape)

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21
Q

Study-Test Modality Shift

A

the process by which people, when presented with information in one modality (reading) and tested in another modality (aurally), display poorer performance than when they are instructed and tested in the same modality

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22
Q

Huntington Disease

A

a hereditary disorder characterized by chorea (ceaseless, involuntary jerky movements) and progressive dementia, ending in death

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23
Q

Classical (Pavlovian) Conditioning

A

a form of nonconscious learning in which a neutral stimulus is paired with a stimulus that evokes behavior

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24
Q

Emotional Memory

A

a memory for the affective properties of stimuli or events that is arousing, vivid, and available on prompting

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25
Q

Fear Conditioning

A

a form of learning in which a noxious stimulus is paired with a neutral stimulus to elicit an emotional response

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26
Q

Panic Disorder

A

a disorder characterized by recurrent attacks of intense terror that arise without warning and without any apparent relationship to external circumstances

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27
Q

Short-Term Memory

A

a system for holding a neural record of recent events and their order used to recall sensory events, movements, and cognitive information such as digits, words, names, or other items for a brief period

28
Q

Proactive Interference

A

interference of something already experienced with the learning of new information

29
Q

Synesthesia

A

sensory mixing

the ability to perceive a stimulus of one sense as the sensation of a different sense

literally, “feeling together”

30
Q

What are the multiple memory systems?

A

different kinds of learning and memory use independent neural processes

31
Q

What are the components of long-term memory?

A

explicit (conscious)

implicit (unconscious)

emotional (conscious and unconsicous)

32
Q

What is explicit memory?

A

episodic: personal, autobiographical

semantic: facts, knowledge

33
Q

What is implicit memory?

A

skills, habits, priming, conditioning

34
Q

What is emotional memory?

A

attraction, avoidance, fear

35
Q

What is short-term memory?

A

sensory, motor, cognitive

~15 seconds, needs rehearsal to keep info active and in there; if something interrupts it, the info is lost

36
Q

What is amnesia?

A

parietal or total loss of memory - resulting from localized brain lesions

37
Q

What is working memory?

A

special case of STM requiring active manipulation of STM contents

38
Q

What three stages does memory function rely on?

A

encoding learning: study processes

“storage” consolidation: rehearsal, re-encoding?

retrieval memory

39
Q

Who was H.M.?

A

bilateral transection of temporal lobes

after surgery, left with anterograde amnesia; some retrograde amnesia

above average IQ

good memory for events before surgery, but unable to describe job he has worked for 6 months

good spatial memory for his immediate surroundings

40
Q

What is anterograde amnesia?

A

inability to acquire new memories

41
Q

What is global anterograde amnesia, like shown in the case of H.M.?

A

impairment in ability to form new memories across a variety of areas (e.g., spatial, semantic)

applies forward from point of trauma

not specific to one sensory system

42
Q

What is retrograde amnesia?

A

inability to remember old memories

43
Q

What is Korsakoff’s syndrome?

A

various types of brain damage related to chronic alcoholism

44
Q

What is infantile amnesia?

A

loss of memory for the early years of life

45
Q

What is transient global amnesia?

A

sudden onset, acute, and short course

loss of old memories and inability to form new memories

concussion, epilepsy, migraine, hypoglycemia

46
Q

What is memory loss during ECT (electroconvulsive shock therapy)?

A

treatment for depression

can produce a transient amnesia: for a short time they experience a loss of memory

47
Q

What was the Squire & Cohen (1979) experiment regarding ECT and details about TV shows?

A

recalling details about popular TV shows that aired for only one season

temporally limited retrograde amnesia in 20 patients

before ECT: most recent memories, a lot of facts recalled
after ECT: real detriment is in the details of most recent shows

most recent memories are not as strongly consolidated as memories made a long time ago

48
Q

What is Ribot’s Law?

A

close to post injury is where memory deficit is worst

5 months: gross disturbance of memory back to infancy, RA total (2 years), AA total (not fixed)

8 months: recovery of memories from childhood, RA partial (4 years patchy memory), RA total (1 year), AA total (3 months), a few new memories recalled

16 months: memory for past events normal, RA total (2 weeks), AA total (3.5 months), new memory precise

after 16 months: 23 weeks residual permanent memory loss

49
Q

What are the symptoms of Korsakoff’s syndrome?

A

anterograde amnesia

retrograde amnesia

confabulation

meager content in conversation

lack of insight

apathy

50
Q

What are the areas of damage in Korsakoff’s syndrome?

A

caused by thiamine (vitamin B1) deficiency

damage may be in medial thalamus, mammillary bodies of hypothalamus, and general atrophy

most patients available for testing

51
Q

What was the experiment involving recognizing famous faces over time?

A

three groups: nonalcoholic control individuals, alcoholic control individuals, patients with Korsakoff’s amnesia

gave pictures of same person across different decades

nonalcoholic patients: do pretty well

alcoholic patients: degradation on memory of most recent pictures, on their way to developing Korsakoff’s

Korsakoff’s patients: do worse on new info, do better on old

conclusion: mammillary bodies will not recover, deterioration will stop if they stop drinking and change diet, will prevent further deficit from occurring

52
Q

What is auditory-verbal working memory?

A

phonological store

input buffer

output buffer

53
Q

What is visual-nonverbal working memory?

A

visuospatial scratchpad

dorsolateral prefrontal cortex (DLPFC): receives info from parietal

54
Q

What is the experiment involving the delayed response paradigm and monkeys with DLPFC bilateral lesions?

A

DLPFC bilateral lesion

food - screen, delay of 1-10s

put food in front of drawers, show monkeys where food is, then put up screen to block view of drawers

after even 1 second delay, lesioned monkeys will perform at chance levels, don’t remember, can’t hold position of food in store

when DLPFC is intact, the monkey will remember where food is

DLPFC: extension of dorsal pathway, strong for visual information

55
Q

What is the single cell DLPFC experiment involving monkeys?

A

the monkey fixes its gaze on the X

after the stimulus (S) disappears the monkey must maintain fixation for a few seconds

finally, it must look to the spatial location where the stimulus had been

56
Q

What is the relationship between the DLPFC and spatial location?

A

find cells that are specific to locations in the visual field

ventral lateral PFC may code for objects

57
Q

What were the results of the meta-analysis of PET and fMRI scans on spatial and object memory?

A

spatial location: more dorsal activation

object recognition: more ventral activation

58
Q

How was working memory spared in the case of H.M.?

A

spared ability to hold small amounts of information over brief periods of time

without hippocampal regions, there is only no consolidation of memory

59
Q

Is the digit span task spared in cases of amnesia?

A

presented with 7 digits (1634589), have to repeat them back

was able to do immediate recall, working off short term memory, working memory is intact

60
Q

Is the extended digit span task spared in cases of amnesia?

A

7 + n task (1634589 + 8; + 2; …), like the game Simon, will add on one more every time

rehearsal consolidates it to LTM

H.M. is capped at short term memory, so did not complete the task

61
Q

Is the delayed non-match-to-sample task spared in cases of amnesia?

A

tested in monkeys with lesioned hippocampus

move eye toward the object that is not the same as sample

if it’s in short-term memory, they’ll do fine

< 10 second delay: correct
> 10 second delay: not correct, they have gone beyond capacity of STM

62
Q

Is skill learning spared in cases of amnesia?

A

practice effects, or more general skill learning?: tested using the mirror reading task

some lines were repeated and one lines were not

patient with amnesia does not remember having done the task in the past, but they show improvement

if they are actually learning a new skill, they’ll get better over time no matter if it repeats or not

improvement on novel lines suggests there are practice effects but they do improve over time

63
Q

How does the mirror drawing task show intact skill learning in patients with amnesia?

A

first time: draw out of the lines more often, over time they get better at the task

brain and body get used to the task

H.M. got better at the task but could not remember having done it; deficit in explicit, fine in implicit

64
Q

How was repetition priming tested in cases of amnesia using the Gollin incomplete pictures task?

A

benefits from previous exposure

when shown the figures again after a delay, intact people recognize the objects at a less complete stage than initially, indicating that prior exposure influences performance

this same effect was shown in patients with amnesia, don’t have recollection of having seen it before, but have implicit memory

65
Q

How did amnesia patients complete the stem completion task?

A

given a word list to memorize

then after delay given stems of words, tasked to fill in the word with whatever comes to mind

initial word list influenced their choice of words, will implicitly fill in the words even though they don’t explicitly remember the first word list

66
Q

What were the deficits H.M. showed in learning new words?

A

hippocampal damage and semantic memory

was not able to learn new words