Lecture 13: Inflammation and healing 1

Question 1

What are the two types of inflammation?

Answer 1

Acute and chronic.

Question 2

What are the effects of acute inflammation?

Answer 2

Early, lasts few days, rapid, features neutrophils, fluid and protein exudate, vasodilation and macrophages. It is non specific.

Question 3

What are the effects of chronic inflammation?

Answer 3

Late response, can last years, features macrophage, lymhocytes, plasma cells.

Question 4

Prevention of blood clotting is via what chemicals? Name 2.

Answer 4

Nitric oxide and prostacyclin.

Question 5

Name a very strong vasoconstrictor.

Answer 5

Endothelin.

Question 6

TNF and IL-1 activate endothelial cells. They incite leukocyte to come in to tissue. What are they guided by? (it’s a type of fibre), and where does this occur?

Answer 6

Fibronectin, in post capillary venules.

Question 7

What is oedema?

Answer 7

Increase in interstitial fluid. This is due to increased hydrostatic pressure, and reduced plasma oncotic pressure.

Question 8

What is hyperemia?

Answer 8

Active process of vasodilation