Lecture 6: Intro To Immunity

Question 0

Name the main differences between innate and adaptive immunity in terms of chemicals used, speed, memory retention and type of recognition used.

Answer 0

Innate uses antimicrobial agents, is fast acting, has no memory retention and recognises PAMPs via different PRRs.

Adaptive uses antibodies, is slow, has a memory and recognises antigens.

Question 1

Name 3 innate immunity cells

Answer 1

NK cells, Epithelial cells, phagocytes such as macrophages

Question 2

Name a family of PRRs.

Answer 2

TLR.

Question 3

True or false? More than one PRR can be recognised on a particular cell.

Answer 3

True

Question 4

What two progenitor cells does bone marrow produce? What cells do they give rise to?

Answer 4

Lymphoid cells that give rise to B, T cells and NK cells.

Myeloid progenitor cells that give rise to granulocytes (basophils, neutrophils, eosinophils) and macrophages and dendritic cells (both from monocytes).

Question 5

What are cytokines? List some.

Answer 5

They are proteins secreted by cells that affect the behaviour of nearby cells that bear the appropriate receptors.

Examples include: interleukins, CSF, tumour necrosis factor TNF.