Lecture 132

Question 1

How long must symptoms last for an juvenile idiopathic arthritis diagnosis?

Answer 1

At least 6 weeks

Question 2

Systemic JIA is also known as:

Answer 2

Still’s disease

Question 3

What is the typical onset of systemic JIA?

Answer 3

1-5 years

Question 4

A daily spiking fever for at least 2 weeks and arthritis in one or more joints in a child is indicative of ____

Answer 4

Systemic JIA

Question 5

A salmon-colored rash, lymphadenopathy, hepatosplenomegaly, and serositis are associated features of:

Answer 5

Systemic JIA

Question 6

What is a serious complication associated with systemic JIA?

Answer 6

Macrophage activation syndrome

Question 7

What JIA subtype is charcaterized by involvement of 4 or fewer joints in the first 6 months?

Answer 7

Oligoarticular JIA

Question 8

Extended oligoarticular JIA involves how many joints after the initial 6 months?

Answer 8

5 or more

Question 9

Oligoarticular JIA typically involves which joints?

Answer 9

Lower extremities

Question 10

What is a key extra-articular complication of oligoarticular JIA?

Answer 10

Uveitis

Question 11

How is polyarticular JIA classified?

Answer 11

Involvement of 5 or more joints in the first 6 months

Question 12

What is the typical joint involvement pattern for RF-negative polyarticular JIA?

Answer 12

Assymetic involvement, often wrists, ankles, TMJ

Question 13

Patients with RF-negative polyarticular JIA that are ANA-positive are at high risk for:

Answer 13

Iridocyclitis

Question 14

What is the typical joint involvement pattern for RF-positive polyarticular JIA?

Answer 14

Symmetrical, affecting large and small joints

Question 15

How is RF-positive polyarticular JIA specifically diagnosed?

Answer 15

RF-positive on two separate occasions, 3 months apart

Question 16

A group of disorders that affect the spine, sacroiliac joints, and often have extra-articular features

Answer 16

Spondyloarthropathies

Question 17

Chronic inflammation of the sacroiliac joints and spine, leading to possible bony fusion describes what spondyloarthropathy?

Answer 17

Ankylosing spondylitis

Question 18

Ankylosing spondylitis has a strong associathion with what HLA mutation?

Answer 18

HLA-B27

Question 19

What are the common complications of ankylosing spondylitis?

Answer 19

Acute anterior uveitis, spinal compression fractures

Question 20

Enthesitis-related arthritis (ERA) typically involves what joints?

Answer 20

Lower extremities, spine, SI joints

Question 21

Dactylitis and nail pitting are signs of what rheumatological disease?

Answer 21

Psoriatic arthritis

Question 22

What type of spondyloarthopathy is associated with inflammatory bowel disease?

Answer 22

Enteropathic arthritis

Question 23

What patient population tends to have peripheral arthritis and is HLA-B27 negative in enteropathic arthritis?

Answer 23

Females

Question 24

What patient population tends to have axial arthritis and is HLA-B27 positive in enteropathic arthritis?

Answer 24

Males

Question 25

Erythema nodosum, bowel involvement, weight loss, and growth delay are extra-articular features of what spondyloarthopathy?

Answer 25

Enteropathic arthritis

Question 26

Pediatric systemic lupus erythematosus (SLE) tends to be MORE/LESS than adult-onset

Answer 26

More severe

Question 27

Neonatal SLA occurs in newborns of mothers with what specific autoantibodies?

Answer 27

Anti-Ro/SSA and anti-La/SSB

Question 28

Congenital third-degree AV heart block, cutaneous rash, and liver involvement are key manifestations of what pediatric inflammatory disease?

Answer 28

Neonatal SLE

Question 29

A heliotrope rash and Grotton papules are characteristic findings of what juvenile inflamamtory disease?

Answer 29

Juvenile dermatomyositis

Question 30

Nectrotizing inflammation of medium-sized arteries describes what pediatric vasculitides?

Answer 30

Polyarteritis nodosa (PAN)

Question 31

What is a typical trigger for polyarteritis nodosa?

Answer 31

Infectious triggers including strep (bacterial superantigens)

Question 32

Conjunctival infection, rash, cervical lymphadenopathy, strawberry tongue, cracked lips, and extermity changes are signs of what pediatric vasculitides?

Answer 32

Kawasaki disease

Question 33

What is a major complication of Kawasaki disease?

Answer 33

Coronary artery aneurysms

Question 34

Henoch-Schonlein purpura (HSP), AKA

Answer 34

IgA vasculitis

Question 35

Purpura on buttocks and legs, arthritis or arthralgias, amdominal pain, and renal involvement are signs of what pediatric vasculitidy?

Answer 35

Henoch-Schonlein purpura (HSP)

Question 36

HSP/IgA vasculitis often follows:

Answer 36

URI

Question 37

What are the treatment options for HSP/IgA vasculitis?

Answer 37

Supportive treatment