Lecture 14

Question 1

What are Hallmarks of Senesence?

Answer 1

Irreversible cell cycle arrest
Macromolecular damage
Deregulated metabolism

Question 2

Can you characterize all senescent cells with 1 marker?

Answer 2

No you need a multi marker approach

Question 3

Senescence-Associated Secretory Phenotype (SASP) are they harmful or beneficial?

Answer 3

Both: Transient SASP = beneficial
Permanent SASP = harmful

Question 4

What does cell size and senesence have in common?

Answer 4

The bigger the cells the more senesence markers exist

Question 5

What triggers senesence?

Answer 5

Tumor suppresors (p53, Rb…)

Question 6

Whats the difference between senolytic and senomorphic?

Answer 6

Senolytic: Killing senescent cells via treatment
Senomorphic: SASP modulating to reduce impact of senescent cells

Question 7

What is p16Ink4a

Answer 7

a critical factor and reporter of celluar senescence
Eliminating leads to increased lifespan