Lecture 16 Flashcards
Name the 3 regions of antibodies
Fc region, Complement binding region and hypervariable region
name the 2 classes for antibody light chains
kappa and lambda
name the 5 antibody classes for antibody heavy chains
Mu, Delta, Gamma, Epilson, Alpha
Which antibody is the most abundant Ig in humans
IgA
Which antibody acts as a trigger receptor by delivering activation signals to naive B cells through antigen binding
IgD
What is the largest antibody
IgM
Which antibody is most abundant in blood
IgG
What is IgE important for?
Allergies and parasitic functions
What do IgG2 and IgG4 do
prevent molecular interaction
What do IgG1 and IgG3 do
activate phagocytic cells
How do IgE molecules bind to mast cells
Via the Fc region
Where is IgD found
On the surface of naive B cells
What is the function of IgA
to prevent harmful material getting through the gut, respiratory tract and provide external body surface protection
where is IgM mostly found
blood
what is the function of IgM
important in defense against blood borne spread of infectious organisms such as bacteria
What do CD8 cells bind to
class 1 MHC
What do CD4 cells bind to
class 2 MHC
what gives TCR their specificity
the different amino acids
what complex does CD8 form
CD8 forms a complex with TCR and CD3
How does T cell recognition work
APC need to be presented with the correct antigen in the correct HLA molecule
what are the class 1 HLA genes
HLA - B, HLA - A, HLA - C
How does clonal repertoire work
the larger the CR then the more antigens we can respond to as the different TCRs provide different interactions
where are class 1 cells found
on all nucleated cells
How does presentation work through class 2 MHC
APC that has endocytosed proteins or dead cells are digested in lysosomes and the resulting fragments are processed and loaded into MHC 2 molecules before they are taken to the surface.
