Lecture 16 T cell mediated immunity

Question 1

3 development of the immune response

Answer 1

1. nonspecific
2. Central (priming) phase
3. T cell effector phase

Question 2

types of professional antigen cells

Answer 2

Dendritic cells
macrophages
B cells

Question 3

Which cells prime naive T cells

Answer 3

dendritic cells

Question 4

TFH express _____ and help B cells

Answer 4

CXCR5

Question 5

What is signal 3?

Answer 5

delivery of cytokines from DC to T cell. Drives differentiation into functional effector role;
match effector response to the specific problem

Question 6

what are the main function of TH1 cells

Answer 6

activate macrophages, provide help with antibody production. They target microbes in intracellular vesicles and extracellular bacteria

Question 7

What is the main function of TH2

Answer 7

they help B cells class switch to IgE. Target helminth parasites

Question 8

What is main function of TH17

Answer 8

• get rid of fungal infections
• maintaining gut epithelial barrier
• enhance neutrophil response
• promote barrier integrity (homeostastis)

Question 9

CTL kills ____

Answer 9

virus infected cells (and cancer)

Question 10

TFH main function

Answer 10

target all kinds of pathogens
help B cells with antibody production, isotype switching

Question 11

CD4 regulatory cells function to

Answer 11

suppress T cell response

Question 12

Which cytokinesspecify TH1 through T-bet?

Answer 12

IFN-gamma and IL-12 through STAT 1 and STAT4

Question 13

what cytokines specify TH2 though GATA-3?

Answer 13

IL4 through STAT6

Question 14

which cytokines specify TH17 through RORgammaT?

Answer 14

TGFbeta, IL23, IL6 though STAT3

Question 15

Which cytokines specify TFH through Bcl-6?

Answer 15

IL6, TGF-beta, IL-21 through STAT3

Question 16

Which cytokines specify Treg through FoxP3?

Answer 16

IL2, TGF-beta, IL10 through STAT5

Question 17

what cytokines do TH1 cells make

Answer 17

IFN-gamma

Question 18

what cytokines do TH2 cells make

Answer 18

IL4, IL5, IL13

Question 19

What cytokines do TH17 cells make

Answer 19

IL17, Il22

Question 20

What cytokines do TFH cells make?

Answer 20

IL21

Question 21

What cytokines do iTreg cells make

Answer 21

TGF-beta, IL10

Question 22

IFN-gamma and CD40L produced by ____ drive fusion of intracellular compartments in ______

Answer 22

TH1; macrophages

Question 23

IL4 activates _____, IL5 activates _______, IL13 helps to enhance barrier mucosal immunity, all produced by ___

Answer 23

mast cells and basoophils;
eosinphils;
TH2

Question 24

IL17 affects ____ cells and IL22 affects ____ cells with which will activate them to recruit _______ to the site of infection. The production of these cytokines is mediated by _____.

Answer 24

stromal cells;
epithelial cells;
neutrophils;
TH17

Question 25

____ produce Il21 that targets B cells and promotes expression of ______ to determine the B cell thats made

Answer 25

TFH; CXCR5

Question 26

____ cells inhibit DCs though expression of IL10, TGF-beta, and IL35

Answer 26

Treg

Question 27

Leishmaniasis is caused by _____ that infect macrophages and dendritic cells. Using susceptible/resistance mice strains and watching the response shows the T cell response that determines resistance. ___ is shown to play a role

Answer 27

sand fly protozoans. TH17

Question 28

BALB/c mice are ______ to Leishmania major because they generate ____ mediated ____ response.

Answer 28

susceptible, IL4, TH2

Question 29

C57/Bl6 are _____ because they generate ______ mediated ____ response

Answer 29

resistant; IFN-gamma; TH2

Question 30

BALB/c mice treated with ______, that reverses ____ response

Answer 30

an antibody that blocks IL-4; TH2/Th1

Question 31

Mycobacterium leprae has a _______ leprosy with TH1 and _______ leprosy with TH2 responses

Answer 31

Th1, Th2

Question 32

IL4 secreted by ___ can inhibit differentiation of _____ cells because they block ____ receptor. Downregulation of STAT4 mediated signaling of this cytokine also decreases ___ production, inhibiting production of ______

Answer 32

TH2, TH1, IL12, IL23, Th17

Question 33

IFN-gamma produced by ___ cells leads to downregulation of ____ and the inhibition of ___ cells and downregulation of ____

Answer 33

TH1, IL4rec, TH2, IgE rec

Question 33

Treg cells can inhibit the production of ___ and ___ cells through the release of TGF-beta

Answer 33

Th1 and TH2

Question 34

effector functions of Th1 cells are

Answer 34

- IFN-gamma and CD40 ligand - Fas ligand or LTbeta - IL2 - IL3 + GM-CSF - TNF-alpha +LTalpha - CXCL2

Question 35

What does Fas ligand or LTbeta do

Answer 35

kills chronically infected cells, releasing bacteria to be destroyed by other macrophages

Question 36

What does IL-2 do?

Answer 36

- induce T cell proliferation - NK cells CTL

Question 37

What does IL3 +GM-CSF do?

Answer 37

induce macrophage differentiation in bone marrow

Question 38

What does TN-alpha + LT alpha do?

Answer 38

activate endothelium

Question 39

What does CXCL2 do?

Answer 39

attracts macrophages to site of infection

Question 40

IL2 produced by ___ activate ___ and ____

Answer 40

CD4+ T cells CD8+ T cells and NK cells

Question 41

CD4+ cells can provide feedback signals to DCs though ____ and _____ leading to release of ___ or ____

Answer 41

IFN-gamma and CD40 L IL10 or IL12

Question 42

Effector cells can respond to target cells ______ stimulation

Answer 42

without