Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Core Concepts in Immunology > Lecture 18: Innate T-cells > Flashcards

Lecture 18: Innate T-cells Flashcards

1
Q

How do conventional T cells recognise peptide antigens ?

A

Presentation by MHC molecules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What do CD8 T-cells recognise ?

A

MHC I

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What do CD4 T-cells recognise ?

A

MHC II

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What do innate T cells recognise ?

A

Non-peptide antigens

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are the innate T cells ?

A
  1. NK T cells
  2. Gamma-delta T cell
  3. MAIT Cell
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What do NK T cells recognise and present ?

A
  1. Lipids
  2. CD1d
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What do gamma-delta T cells recognise and present ?

A
  1. Phospoantigen
  2. Butyrophilins
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What do MAIT cells recognise and present ?

A
  1. Metabolite
  2. MR1
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

How do innate T cells recognise non-protein antigens ?

A

TCR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What type of response do innate immunity have ?

A

Pre-existing, speedy response

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What type of response do adaptive immunity have ?

A

Learned and specific response

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What links innate and adaptive immunity ?

A

Innate t-cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are innate T cells ?

A

Effector cells that do not require prior antigen primining

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are some lipid antigens from bacteria that NKT cells recognise ?

A
  1. Agelasphins
  2. Alpha- glucuronosylceramide
  3. Phosphatidylinositol mannoside
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are iNKT cells ?

A

Type 1 or invariant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What do iNKT cells recognise ?

A

Alpha-galactosylceramide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

How do iNKT cells recognise Alpha-galactosylceramide ?

A

A semi invariant VA24VB11 T cell recptor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What are depleted in humans with most cancers ?

A

iNKT Cells

19
Q

What do iNKT cells regulate ?

A

Metabolism

20
Q

What are some effector functions of human iNKT cells ?

A
  1. Kill CD1d+ target cells
  2. Rapid release of Th1, Th2, Th9, Th17 and Treg cytokines
  3. Activate macrophages and NK cells
  4. Regulate neutrophils and MDSC
  5. Promote maturation of dendritic cells into antigen presenting cells
  6. Promote maturation of B cells into antibody secreting plasma cells
21
Q

What do iNKT cells transactivate ?

A

Into other immune cells

22
Q

What are the murine iNKT cells ?

A
  1. CD4
  2. DN
  3. CD8alpha
23
Q

What is the function of CD4 ?

A

Th2 cytokines

24
Q

What is the function of DN and CD8alpha ?

A

Ctytolytic activity and Th1 cytokine s

25
What can alter the Th1/Th2 cytokine bias of INKT cells ?
Glycolipids
26
What do type 2 NKT cells recognise ?
Glycolipids presented by CD1d
27
What do type 2 NKT cells express ?
Diverse T cell receptors
28
What do type 2 NKT cells recognise ?
Tumour derived ganglioside GD3 and sulpfatide in neurons
29
How do type 2 NKT cells promote cancer ?
IL13
30
What are the functions of gamma-delta T-cells ?
1. Lysis of infected or stressed cells 2. Cytokine and chemokine production 3. B cell help and IgE production 4. Primary alpha-beta T cells via antigen presentation 5. Dendritic cell maturation 6. Regulation of stromal cell function by growth factor production
31
Where are gamma-delta T cells expanded ?
gut, liver and adipose tissue
32
What do gamm-delta T cells mediate ?
Pathogen clearance
33
What are the three subsets of gamma-delta T cells ?
1. V delta 1 2.Vgamma9Vdelta2 3.Vdelta3
34
What do Vdelta2 T cells recognise and what are they presented by ?
1. Pyrophosphate antigens 2. Butrophilin 3A1
35
What does Vgamma9Vdelta2 T cells recognise ?
Intermediates of isoprenoid synthesis
36
What accumulate IPP ?
Tumour cells and aminobisphonate treated cells
37
What are the functions of Vgamma9Vdelta2 T cells ?
1. Cytotoxicity 2. Th1 cytokine secretion 3. Activation of neutrophils 4. Induction of monocyte maturation into DC 5. Induction of DC maturation into APC 6. B cell help/antibodies 7. Antigen presentation
38
Where is Vdelta1 T cells expanded ?
1. Expanded in healthy gut and liver 2. Expanded in patients with CMV activation, chronic HBV, HIV and B-CLL
39
How can Vdelta T cells be activated ?
1. Stress inducible proteins MICA and MICB 2. Glycolipids presented by CD1c and CD1d 3. algal protein phycoerythrin
40
What can Vdelta1 T cells be activated by the ligation of ?
1. NKG2C 2. NKG2D 3.NKp30 4. TLR 5. Dectin 1
41
What do MAIT cells recognise and what is it presented by ?
1. B9 and B2 2. MR1
42
What do MAIT cell kill ?
Bacteria that are capable of synthesising riboflavin
43
What are the function of MAIT cells ?
1. Lysis of infected cells 2. Recrutiment of adaptive cells 3. Activation of immune cells
44
What disease are MAIT cells synthesised in ?
1. Ulcrative colitis 2. Crohns 3. Multiple sclerosis 4. Type 1 diabetes 5. Inflammatory arthirits 6. Asmtha 7. Lupus nephritis

Core Concepts in Immunology (22 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions