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Biochemistry Exam 2 > Lecture 19 Part 2 > Flashcards

Lecture 19 Part 2 Flashcards

1
Q

Slide 39 What is a Hematoma?

A

??

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2
Q

What is a soft cal

A

..

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3
Q

How long does it take to repair the fracture process?

A

..

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4
Q

What is the green area on slide 41?

A

never mind

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5
Q

After 6 weeks, you can see the vascularization taking place slide 42

A

white is the marrow

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6
Q

What does fracture healing require?

A

VEGF

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7
Q

Slide 43

A

..

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8
Q

What happens during the early phase of imapired healing in Osteoporotic fractures?

A

In normal: In osteoporotic:

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9
Q

What happens during the Midphase of osteoporotic fractures?

A

In normal: In osteoporotic:

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10
Q

What happens during the late phase of osteoporotic fractures?

A

In normal: In osteoporotic:

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11
Q

What is the hall mark of tumor development?

A

Angiogenesis

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12
Q

How do tumors become highly vascularized?

A

By using growth factors like VEGF

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13
Q

How doe VEGF opetate in tumor growth?

A

….

  1. In early tumor development, VEGF can help establish a new vasculature
  2. As the vasculature networks develops, VEGF can dontinue to help new vasculature grow…
  3. slide 48..
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14
Q

What is the role of VEGF in tumor angiogenesis?

A

Slide 50

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15
Q

Whats hapening on slide 50

A

slide 50

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16
Q

whats happening on slide 51

A

….

17
Q

What inhibits Angiogenesis?

A

Enostatin and Angiostatin

18
Q

What is Endo statin?

A

Endostatin is naturally occuring,

serves as an anti-angiogenic angent

19
Q

What is Angiostatin?

A

38kd

is part of a bigger protein called plasmin

Plasmin itself is part of another big protein called plasminogen

20
Q

How do you start from Plasminogen and get all the way to Angiostatin?

A

Slide 54

21
Q

What are Anti-angiogenic Cancer therapies?

A

Slide 55

22
Q

What are the side effects of using Anti-angiogenic Cancer therapies?

A
23
Q

Where can Anti-angiogenic Cancers therapies interfere with the normal actions of VEGF?

A
24
Q

Explain what’s happening in this slide

Endostatin Treatment

A

Slide 57

…

as soon as they stop treatment, the tumor reappeared

after a second round of endostatin, tumor was mininmized to the point of very little regrowth

Need to reduce tumor growth to 0?

25
Q

KNOW SLIDE 58

A

Tyrosice activity

26
Q

What is the mechanism of action of anti cancer angiogenesis inhibitors VEGF

A

Slide 59

27
Q

What does ATP do in this slide

A

Slide 60

28
Q

What is Macular degeneration result?

A

Vision loss,

center of vision field is blurry or abscent

b/c there’s a mass in the eye blocking the vision

Slide 61

29
Q

What’s happened in slide 62

A

slide 62

30
Q

slide 63

A

?

31
Q

What is demonstrated in slide 64

A

VEGF is required for vascularization

32
Q

What’s the monoclonal antibody therapy?

A

Biochemistry Exam 2 (7 decks)

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