lecture 2 Flashcards

(46 cards)

1
Q

Sources of Drug Derivation

A
  1. PLANTS: Grouped by their physical and chemical properties

Alkaloids (atropine, nicotine, morphine)

Glycosides (digoxin)

  1. HUMANS/ANIMALS: (e.g., hormones, enzymes)
  2. MINERALS: Sodium, iodine, potassium, iron, gold
  3. SYNTHETIC SOURCES: Do not exist in nature, can be organic or inorganic.

Ex. Contraceptives, Demerol, sulfonamides

  1. ENGINEERED SOURCES: Result of gene splicing or genetic engineering (insulin, tPA, GH).
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2
Q

Drug Forms (5)

A

Oral pills and tablets (systemic or local)

Injectable medications

Dermally applied

Rectal or vaginally administered (systemic or local)

Other (otic, ophthalmic, etc) (usually local)

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3
Q

Pills

A

powdered drug mixed with liquid and rolled into round or oval shape

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4
Q

Tablets

A

powdered form of drug and bulk-filling material compressed under high pressure; various types include:
Chewable, sublingual, buccal, and buffered.

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5
Q

Capsules

A

external shell usually made of gelatin contains drug in powder, granule, liquid, or combination form.

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6
Q

Sustained release:

A

Different doses are coated to dissolve at different rates (gradual increase rather than a sudden peak)

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7
Q

Enteric-coating

A

prevents capsule or tablet from being dissolved in stomach where it may cause irritation; (dissolves more in small intestine)

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8
Q

Caplets

A

shaped like capsules with form of tablets; film-coated for easy swallowing

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9
Q

Gelcaps

A

oil-based drug in soft gelatin capsules

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10
Q

Powders

A

dried and finely ground drugs

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11
Q

Granules

A

tiny pills usually in gelatin capsules; usually intended for gradual release

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12
Q

Troches or lozenges

A

flattened disks that may be hard or semisolid (ex.cough suppressants, Halls)

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13
Q

Syrups

A

aqueous solutions containing high concentrations of sugars

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14
Q

Solutions

A

drugs dissolved in appropriate solvent

ELIXERS: solutions of water, alcohol, and sugar

FLUID EXTRACTS: Concentration solution of a drug removed from plant by mixing with a solvent

MIXTURES AND SUSPENSIONS: A mixed solid liquid that do not dissolve – must be shaken before use

TINCTURES: An alcoholic preparation of a soluble drug

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15
Q

Emulsions

A

A preparation in which 2 agents that cannot ordinarily be combined. (Ex. creating Creams and lotions)

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16
Q

Spirits or Essences:

A

An alcohol-containing liquid that may be used pharmaceutically as a solvent.

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17
Q

Infants and young children

A

Not able to take solid drug forms such as tablets or capsules.

LIQUID drugs should be used.

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18
Q

Liniments: topical liquid

A

liquid suspensions for external application to skin

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19
Q

Gels or jellies: topical liquid

A

jellylike substances used for topical application

20
Q

Lotions: topical liquid

A

suspensions of drugs in water base for external use

21
Q

Creams: topical semi-solid

A

semi-solids in both aqueous and oily base (e.g., benzoyl peroxide)

22
Q

Ointment: topical semi-solid

A

similar to creams; used for local protective, soothing, astringent, or transdermal systemic effects (e.g., zinc oxide)

23
Q

Plasters: topical semi-solid

A

combination liquids and powders that harden when dry (e.g., salicylic acid)

24
Q

Transdermal patches: topical

A

Constant, time-released systemic effect (Ex. Nicotine, estrogen, nitroglycerin)

Many things impact transdermal absorption, making sure med gets through not too fast or too slow (ex. sweating can have an impact)

25
Enteral route: oral
Most common, easiest, and most economical Contraindicated if patient is vomiting, has gastric or intestinal suction, is unconscious, or is unable to swallow. (Don’t try to get somebody unconscious, already vomiting, etc… to take a pill (it won’t be swallowed at all, or it will quickly come back up)) Liquid medications are best for children. Contraindication is a condition or factor that increases the risks involved in using a particular drug, carrying out a medical procedure, or engaging in a particular activity.
26
Enteral route: nasogastric
Nasogastric (NG) tube: inserted through nasopharynx and into stomach
27
Enteral Route: Gastrostomy
Gastrostomy tube: surgically placed directly into stomach
28
Enteral Route: Sublingual
Sublingual: placed under tongue for dissolving Used when RAPID ACTION is desired Examples include nitroglycerin (for angina pectoris) and ergotamine tartrate (for migraines) **lots of med are more concentrated than you need because parts of it are eliminated throughout the body, but sublingual route cancels that out because you aren’t swallowing it
29
Enteral Route: Buccal
Buccal: Placed between gum and cheek for dissolving Forms include tablets, capsules, lozenges, and troches Should not be swallowed Often used over sublingual route for SUSTAINED-RELEASE delivery
30
Injected Drugs
Provide rapid response; also called PARENTERAL Administered by following methods: 1.Intra-articular (joint) 2.Intradermal 3.Intramuscular (IM) 4.Epidural (back) 5.Subcutaneous 6.Intravenous (IV)
31
Parenteral Routes-injected
More quickly absorbed than oral route Irretrievable once injected (unlike pills, where you can induce vomiting) Require invasive procedure Aseptic (sterile) technique must be used to avoid infection.
32
Ampules
made of clear glass; usually contain single dose of drug; usually have pre-scored neck that is cut open; medication is then aspirated into syringe using filter needle Not very common anymore… glass can get in there when taking off the top, which could be injected
33
Vials
small glass bottles sealed with rubber cap; pierced with needle to withdraw medication Rubber falling into solution causes a recall
34
Intradermal Injection (ID)
Needle enters at 15° angle Usually given in inner forearm or upper back just below epidermis into dermis Commonly used for tuberculin or allergy tests, or to administer local anesthetics Injection produces small wheal on skin’s outer surface
35
Subcutaneous Injection
45º angle usually used, based on patient’s body weight Usually given into upper arms, back, or abdomen Commonly used for heparin and insulin Small volumes of medication (0.5 to 1 mL) are given subcutaneous.
36
Intramuscular (IM) Injections
90º angle is usually used; Usually given into upper arm, thigh, or hip muscles Commonly used for drugs that irritate subcutaneous tissue 1 to 3 mL of medication can be given IM.
37
Intravenous Injection (IV)
IV needles are inserted into veins at a SHORT ANGLE (ex. 10-30deg?) to the skin. Injected directly into veins, usually in arms May be administered: -Slowly -Rapidly (IV push) (quick drip) -Piggyback infusion- adding a second drug to the same line, ie. antibiotics -Into existing IV line (IV port) -Into intermittent access device (heparin lock), or added to IV solution
38
Autoinjectors
Autoinjectors are self-injectable devices; Deliver drugs through subcutaneous or intramuscular route. They enclose prefilled syringes or cartridges which are driven by a spring system. *You’re injecting a lot of med into one spot and it should spread systemically but they can be irritating *You should have 2 epipens cause sometimes the first one doesn’t work
39
Aerosols: other forms
Frequently delivered by oral inhalers or nebulizers for rapid absorption into BLOOD circulation Most commonly used for conditions in the lungs. *the lung’s job is to absorb things systemically (heart rate speeds up) *use these for colds and flus as well as for asthma (they can treat things from viral infections to asthma attacks)
40
Ophthalmic: other forms
eye drops and ointments route: -Medications are administered to the eyes using instillations (drop?) or irrigations (flush?) with liquids or ointments. -Sterile technique is required. -Prescribed liquids are usually diluted to less than 1% strength. -Eye irrigations are used to wash out conjuctival sac
41
Otic: other forms
ear medications route: -Localized infection or inflammation of the ears is treated by dropping a small amount of sterilized medication into the ear. -Patient should remain lying on one side for 5 minutes to allow coating of inner ear canal with medication.
42
Nasal: other forms
nose drops or sprays route: -Nasal decongestants are most common nasal instillations. -Many of these medications are OTC drugs. -Administered with dropper or via sprays; usually while patient is supine with head tilted back -Intranasal medications include antiepileptics, opiate analgesics and opiate antagonists, sedatives, topical anesthetics, glucagon for hypoglycemia, and agents for epistaxis control. -Some vaccines can be administered intranasally (reduces trauma for children)
43
Vaginal: other forms
solutions, creams, tablets, suppositories (rare for systemic, usually for vaginal specific issues) route: -Vaginal medications, or instillations, include creams, jellies, foams, or suppositories -Suppositories are inserted with the finger of a gloved hand; they melt at body temperature. -Vaginal creams may be instilled by using an applicator. *this is also how they do in vitro fertilization
44
Rectal
suppositories or enemas (liquid to help poop) (sometimes used when people are vomiting) route: -Rectal medications are usually suppositories. -This route is useful for patients who are nauseated, vomiting, or unconscious. -Other rectal medications are available as solutions that are administered in the form of enemas (liquid into rectum to help poop) **need to push it past the sphincter, far enough up, so it doesn’t come back out *good for kids who are vomiting or have trouble taking other forms of medication
45
Inhalation route
Inhalation therapy may involve the administration of medicines, water vapor, and gases such as oxygen, carbon dioxide, and helium Local effects are achieved within the respiratory tract through aerosols, nebulizers, or metered-dose inhalers. *most things through the lungs get absorbed!!
46
Inhaled Asthma Medications
Commonly administered by NEBULIZER -Delivers fine fog or mist using atomization or aerosolization ATOMIZATION: larger droplets are inhaled AEROSOLIZATION: droplets are suspended in gas such as oxygen (the smaller the droplets, the further they can be inhaled into the respiratory system)