lecture 2 Flashcards
(46 cards)
Sources of Drug Derivation
- PLANTS: Grouped by their physical and chemical properties
Alkaloids (atropine, nicotine, morphine)
Glycosides (digoxin)
- HUMANS/ANIMALS: (e.g., hormones, enzymes)
- MINERALS: Sodium, iodine, potassium, iron, gold
- SYNTHETIC SOURCES: Do not exist in nature, can be organic or inorganic.
Ex. Contraceptives, Demerol, sulfonamides
- ENGINEERED SOURCES: Result of gene splicing or genetic engineering (insulin, tPA, GH).
Drug Forms (5)
Oral pills and tablets (systemic or local)
Injectable medications
Dermally applied
Rectal or vaginally administered (systemic or local)
Other (otic, ophthalmic, etc) (usually local)
Pills
powdered drug mixed with liquid and rolled into round or oval shape
Tablets
powdered form of drug and bulk-filling material compressed under high pressure; various types include:
Chewable, sublingual, buccal, and buffered.
Capsules
external shell usually made of gelatin contains drug in powder, granule, liquid, or combination form.
Sustained release:
Different doses are coated to dissolve at different rates (gradual increase rather than a sudden peak)
Enteric-coating
prevents capsule or tablet from being dissolved in stomach where it may cause irritation; (dissolves more in small intestine)
Caplets
shaped like capsules with form of tablets; film-coated for easy swallowing
Gelcaps
oil-based drug in soft gelatin capsules
Powders
dried and finely ground drugs
Granules
tiny pills usually in gelatin capsules; usually intended for gradual release
Troches or lozenges
flattened disks that may be hard or semisolid (ex.cough suppressants, Halls)
Syrups
aqueous solutions containing high concentrations of sugars
Solutions
drugs dissolved in appropriate solvent
ELIXERS: solutions of water, alcohol, and sugar
FLUID EXTRACTS: Concentration solution of a drug removed from plant by mixing with a solvent
MIXTURES AND SUSPENSIONS: A mixed solid liquid that do not dissolve – must be shaken before use
TINCTURES: An alcoholic preparation of a soluble drug
Emulsions
A preparation in which 2 agents that cannot ordinarily be combined. (Ex. creating Creams and lotions)
Spirits or Essences:
An alcohol-containing liquid that may be used pharmaceutically as a solvent.
Infants and young children
Not able to take solid drug forms such as tablets or capsules.
LIQUID drugs should be used.
Liniments: topical liquid
liquid suspensions for external application to skin
Gels or jellies: topical liquid
jellylike substances used for topical application
Lotions: topical liquid
suspensions of drugs in water base for external use
Creams: topical semi-solid
semi-solids in both aqueous and oily base (e.g., benzoyl peroxide)
Ointment: topical semi-solid
similar to creams; used for local protective, soothing, astringent, or transdermal systemic effects (e.g., zinc oxide)
Plasters: topical semi-solid
combination liquids and powders that harden when dry (e.g., salicylic acid)
Transdermal patches: topical
Constant, time-released systemic effect (Ex. Nicotine, estrogen, nitroglycerin)
Many things impact transdermal absorption, making sure med gets through not too fast or too slow (ex. sweating can have an impact)