Lecture 2 Flashcards
(12 cards)
What s the role of receptor in cellular physiology
Neurotransmission, cellular delivery (letting material into cell), cell adhesion, gene expression, immune response, regulating intracellular calcium stores
How are receptors classified?
Based on their agonist and how tightly a series of antagonists binds them.
What is the difference between a receptor and an acceptor?
Receptor is silent until activated. An acceptor can operate in the absence of ligand e.g sodium channels
Receptors with integral ion channels?
Nicotine acetylcholine receptor gated sodium, potassium and calcium channels
Gamma amino butyric acid (gaba) receptor with a chloride channel
Give an example of a receptor with enzymatic activity and it’s ligand
Tyrosine kinase receptor and insulin
Give an example of a membrane bound receptor that signals through a transduction protein?
G protein coupled receptors
Beta adrenoreceptors on adrenaline binding, cAMp activated via a G protein
How do intracellular receptors work?
On binding inhibitory protein complex removed due to conformational change. DNA is then exposed (zinc fingers) eg oestrogen receptor
Give an 3xamoke of cellular activation and inhibition
Hepatocytes:
Insulin stimulates to make glycogen
Glucagon stimulates to break down glycogen
What is a receptor?
Molecules that recognises specifically a second molecule or ligand or family of molecules and in response to ligand binding can regulate cellular processes
Intracellular receptors example?
Vitamin D and oestrogen
Noradrenaline action on heart?
Increase heart rate through activation of beta 1 adrenoreceptors
Noradrenaline action on heart?
Increase heart rate through activation of beta 1 adrenoreceptors
