lecture 2 Flashcards
(13 cards)
how did Golgi visualize neurons
soaked and stained brains in solution
what are the four regions of a neuron
- soma
- axon and axon collaterals
- dendrites (spiny or smooth)
- pre synaptic release sites (terminals, boutons and non-localized sites)
what does the size of a dendrite indicate about a neuron
its convergence (inputs) the territory that neutron will pay attention to
cell body characteristics
main metabolic centre of neuron- lots of. mitochondria
site of protein synthesis- lots of endoplasmic reticulum
around 8-200um
dendrites characteristics
primary sites of INPUT from other neurons can release Its contains ribosomes (can make proteins) vary in diameter contain lots of actin
axon characteristics
specialized for relaying electrical signals (conduct AP)
vary in length but constant diameter
contain microtubules and MTBP - involved in transport
always have specialized areas to release NTs
how do neutrons communicate with eachother
synapses
what is a directed synapse
transmitter is released onto a receptor ~15nm away from the cleft
ex. axo-dendritic, axo-somatic, axo-axonic
what is a non directed synapse
transmitter is released onto a synapse many um away
what is 2 photon microscopy
Winifred denk- concept that putting in 2 red photons very fast will act the same way as 1 blue would - can use green fluorescence using red light
spine characteristic
compartmentalize biochemical processes driven by calcium
produce amplification of local voltage changes if voltage gated channels are in spine head
what is convergence
the number of inputs to a single neuron
what is divergence
number of targets innervated by one neuron