Lecture 20: Drug Interactions Flashcards Preview

FB2 drug list > Lecture 20: Drug Interactions > Flashcards

Flashcards in Lecture 20: Drug Interactions Deck (12)
Loading flashcards...
1
Q

Pharmacodynamic interaction of Atenolol (β antagonist) & Salbutamol (β2-agonists)

A

Antagonism: β-receptor antagonists reduce the effectiveness of β2-agonists.

2
Q

Pharmacokinetic Interaction of Cimetidine

A

Altered Metabolism: Enzyme inhibition: increased risk of bleeding.

3
Q

Pharmacokinetic Interaction of Iron

A

Altered Gastrointestinal Absorption:

Iron or antacids containing aluminum or calcium can chelate tetracycline & reduce its absorption and effectiveness.

4
Q

Pharmacokinetic Interaction of Phenobarbital

A

Altered Metabolism:

Enzyme induction → (inducers) accelerate the metabolism of many drugs.

5
Q

Pharmacokinetic Interactions of Probenecid

A

Altered Renal Elimination (Excretion):

Inhibition of active tubular secretion (important and beneficial).

6
Q

Pharmacokinetic Interactions of Salicylate

A

-Altered Renal Elimination (Excretion)
●Inhibition of tubular re-absorption via changing the ratio of non-ionized to ionized fractions by altering pH of the urine.
E.g. making urine alkaline to increase excretion of salicylates (aspirin).

7
Q

Pharmacodynamic interaction of Salicylate

A

-Additive effect

●Increased risk of bleeding when aspirin is co-administered with the anticoagulant warfarin

8
Q

Pharmacokinetic Interaction of Tetracyclines

A

-Altered Gastrointestinal Absorption

●Iron or antacids containing aluminum or calcium can chelate tetracycline & reduce its absorption and effectiveness.

9
Q

Interaction of Diet and Drugs of Tetracyclines

A

Tetracycline with milk products (Ca 2+) resulting in decreased absorption of the antibiotic.

10
Q

Pharmacokinetic Interaction of Warfarin (Altered Drug Distribution)

A

-Displacement from protein binding sites:
●Many drugs are highly bound to plasma proteins.
●Displacement from protein binding sites by other drugs increases the concentration of free form of the object drug leading to increased pharmacological activity.

11
Q

Pharmacokinetic Interaction of Warfarin (Altered Metabolism)

A
  • Enzyme induction

- Enzyme inhibition: increased risk of bleeding

12
Q

Pharmacodynamic interaction of Warfarin

A

-Additive effect

●Increased risk of bleeding when aspirin is co-administered with the anticoagulant warfarin