Lecture 25+26+DLA Flashcards

(44 cards)

1
Q

potential ADE

A

an error that is intercepted before reaching the patient

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2
Q

preventable ADE

A

an error that reaches the patient and causes some degree of harm

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3
Q

non-preventable ADE

A

an adverse outcome though medications are prescribed and administered appropriately

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4
Q

the causes of medication errors

A
  1. patient specific causes
    EX: elderly taking multiple medications are more vulnerable to ADE
  2. drug specific causes
    EX: look alike or sound alike meds
  3. clinician specific causes:
    unnecessary drug prescription, transcribing errors, dosage errors, failure to identify a drug allergy
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5
Q

how to to reduce medication errors?

A

transcription training

using the 5R’s
(right drug, right patient, right does, right route, right time)

CPOE (computerized physician order entry)

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6
Q

how to reduce hospital-acquired infections

A
  1. hand washing- single most affective method

more sinks
more alcohol based hand rubs
no artificial nails
changing gloves

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7
Q

risk factors for patient falls

A
  1. over the age of 60
  2. taking multiple drugs (sedatives, hypnotics, antidepressants)
  3. impaired memory
  4. difficulty walking
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8
Q

how to reduce patient falls

A
  1. identify high risk people
  2. education
  3. safety rounds
  4. bed alarms
  5. safety companions
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9
Q

no-fault errors

A

Result from factors outside the control of the clinician or the health care system

Ex: atypical disease presentation
patient providing misleading info; uncooperative

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10
Q

systems-related error

A

The result of technical or organizational flaws

EX: 
inadequate communication and care coordination 
inefficient processes
technical failure  
equipment issues
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11
Q

cognitive errors

A

diagnoses that are wrong, missed, or unintentionally delayed due to clinician error

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12
Q

Anchoring bias

A

A wrong diagnosis made when clinician maintains initial
impressions when making a diagnosis, and becomes
dismissive to signs and symptoms that points to another diagnosis

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13
Q

confirmation bias

A

Looking for evidence and interpretation of information to fit a preconceived diagnosis rather than the converse

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14
Q

Availability bias

A

More recent and readily available answers and solutions are preferentially favored because of ease of recall and incorrectly perceived importance

most cognitively available diagnosis

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15
Q

Diagnosis Momentum

A

When the diagnosis considered by one clinician becomes the definitive diagnosis as it passed from one clinician to the next; it then becomes accepted without
question by clinicians down the line

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16
Q

framing effect

A

Diagnostic decision-making unduly biased by extraneous and collateral information

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17
Q

slips (medical error)

A

Actions not carried out as intended or planned

Ex: giving an iv injection instead of subcutaneous

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18
Q

lapses (medical error)

A

missed actions and omissions

ex: forgetting to monitor a patient and replacing serum K in a patient with AHF

19
Q

Mistakes (medical error)

A

A wrong intended action

e.g., a faulty plan or incorrect intention

20
Q

violation

A

not a type of medical error

Deliberate actions whereby someone does something and knows it to be against the
rules

EX: deliberately failing to follow proper procedures

21
Q

near-miss (outcome of medical error)

A

Errors that occur but do not result in injury or harm to patients because they are caught in time or simply because of luck

22
Q

adverse events (outcomes of medical errors)

A

Harm or injury that results directly from the management of a patients’ disease or condition by health care professionals rather than by the underlying disease or condition itself

23
Q

Sentinel event (outcome of medical error)

A

Adverse event in which death, permanent or severe temporary harm to a patient has occurred; used to refer to events that were not at all expected or acceptable

24
Q

Never Event / Serious Reportable Events (outcome of medical error)

A

adverse events in medical care that are clearly identifiable, preventable, and serious in their consequences for patients, and that indicate a real problem in the safety and credibility of a health care facility

Ex: 
surgical events
product events 
care management events 
potential crime event
25
Factors that contribute to Unsafe Care
``` communication and teamwork failure errors at hand off stress and fatigue poor working conditions lack of education ```
26
what mediates signaling in B cell receptors?
Ig alpha and Ig beta BCR's are antibodies
27
the light chain
``` The amino (N) terminal domain is variable and the site of antigen binding ``` the constant domain at the carboxy terminal; it can be kappa or lambda
28
The heavy chain
this chain determines the 5 classes of Ig: G, A, M, E, and D ``` Constant region (C): nearly invariant; not involved in antigen binding ```
29
IgG
monomer, produced by plasma cells (primary response) and memory cells (secondary), most prevalent 2 binding sites most common in serum can cross placenta binds to phagocytes long term immunity memory Ab's neutralizes toxins and viruses
30
IgA
2 or 4 binding sites does not cross placenta binds to epithelial cells secretory Ab on mucous membranes
31
IgM
10 binding sites does not cross placenta first to be produced in response to antigen can serve as a B cell receptor
32
IgD
2 binding sites does not cross placenta receptor on B cells for antigen recognition
33
IgE
2 binding sites does not cross placenta binds to mast cells and basophils the antibody of allergy; worm infections
34
T cell receptor
heterodimer recognizes peptides displayed by MHC molecules composed of an alpha and beta chain each with a V and C region do not undergo class switching
35
TCR complex
it can recognize the antigen but does not transmit signals complex with 3 dimers associated with CD3 needs a coreceptor (CD 4 or 8)
36
Lymphopoiesis
B cell production occurs throughout life; does not wane as does T cell production process in which lymphocytes develop from progenitor cells
37
B cell development
the goal is to produce plasma and memory cells 1. antigen-independent phase (bone marrow) 2. antigen-dependent phase 3. Differentiation of active B cells into plasma and memory cells
38
antigen independent phase of B cell development
``` pro B cells: expression of CD45R and CD 19 IL 7 supports this process successful re-arrangement of the ig heavy chain = pre-B cells Tdt catalyzes the heavy chain coding ``` pre-B cells: seen to have igu heavy chain in cyto induce recombination of ig light chains
39
BTK
Bruton's tyrosine kinase (BTK) is a kinase that plays a crucial role in B-cell development Mutations in the BTK gene are implicated in the primary immunodeficiency disease: X-linked agammaglobulinemia (XLA) the pre-B cells fail to mature BTK inhibitors are used in the treatment of some cancers and autoimmune diseases
40
immature B cells
IgM is expressed on the surface negative selection occurs (clonal deletion) functional B cell receptor appears
41
mature B cell expresses?
IgM and IgD | involves a change in RNA processing of the heavy chain
42
naive B cells
migrate out of the bone marrow no dividing no antigen encounter
43
negative selection; thymocyte
Elimination of any CD4 or CD8 cells that have high affinity to selfMHC alone or to self MHC-self epitope complexes these cells are programmed to die ensures self-tolerance
44
AIRE
autoimmune regulator; transcription factor expressed in the medulla of the thymus drives negative selection of T cells ( so body does not attack itself) when AIRE is defective it can lead to autoimmune disease