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Lecture 25: Antivirals Flashcards

1
Q

What are Viruses?

A

Obligate intracellular parasites

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2
Q

What does it mean to be an obligate intracellular parasite?

A

They rely on host biosynthetic machinery to reproduced

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3
Q

What do viruses exist as when not inside an infected cell?

A

They exist as independent particles called virions

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3
Q

What do viruses exist as when not inside an infected cell?

A

They exist as independent particles called virions

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4
Q

What do Virions consist of?

A
  • Double or single stranded DNA or RNA
  • A protein coat (capsid)
  • Some possess a lipid envelope
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5
Q

What is the Capsid?

A

The protein coat of a Virion

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6
Q

What is the lipid envelope of a virion derived from?

A

The host cell

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7
Q

What can the genetic material of a Virion be?

A

Double or single stranded DNA or RNA

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8
Q

What can the lipid envelope or protein coat of a virion contain?

A

Antigenic glycoproteins that can infect the host

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9
Q

What is the viral range?

A

The group of cell types (or species) that a virus can infect

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10
Q

What is the size comparison between a virus and a bacterium?

A

Viruses are 1/100th of the average bacterium

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11
Q

What is a Bacteriophage?

A

Viruses that only infect bacteria

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12
Q

What do most animal viruses not cross?

A

Phyla, and some only infect closely related species

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13
Q

What are the three virus shapes?

A

Helical, Icosahedral, Complex

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14
Q

What is pathogenicity?

A

The ability of viruses to cause disease

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15
Q

What is Virulence?

A

The degree of pathogenicity

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16
Q

What is latency?

A

When some viruses can remain dormant in organisms

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17
Q

What are carriers?

A

People chronically infected and that serve as reservoirs of infectious viruses

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18
Q

Do all viruses cause disease?

A

No, there a GI viruses and skin viruses that are part of the microbiome

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19
Q

What does it mean to be low virulence?

A

Does not cause significant disease in humans

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20
Q

What does the virulence of a virus change depending on?

A

The type of the virus and from person to person

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21
Q

What is the difference between pathogenicity and virulence?

A

Pathogenicity is just does it cause disease or not? And if it does cause disease virulence is the intensity of the disease

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22
Q

What are the four steps in the life cycle of viral replication?

A
  • Absorption
  • Penetration
  • Replication
  • Release
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23
Q

What do the surfaces of viruses have?

A

Proteins that bind to receptor protein on the host cell

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24
What determines the host range of a virus?
The surface proteins of a virus that bind to a receptor protein on a host cell
25
What begins the infection process of a virus?
The surface proteins of a virus binding to the receptor protein on a host cell
26
What happens once binding proteins on viruses bind to receptors on the host cell?
Viral DNA or RNA crosses the cytoplasm or nucleus
27
What happens once a virus enters the cell?
Viral DNA or RNA interacts with host machinery for translating DNA or RNA into viral protein
28
What happens once newly synthesized viral protein is created in the host cell?
Newly synthesized virion particles are released to continue infection cycle
29
What are the two types of viruses?
RNA and DNA viruses and can be single-stranded or double double-stranded
30
What do most DNA viruses do?
Enter the host cell nucleus where the viral DNA is integrated into the host genome and transcribed into mRNA
31
What transcribed DNA viruses into mRNA?
Host DNA-dependant RNA polymerase
32
What is an exception to DNA viruses and why?
Poxviruses carry their own DNA-dependant RNA polymerase
33
What does viral genome replication of viruses require?
DNA dependant DNA polymerase from the host or virus
34
Where can pox viruses replicate and why?
They replicate in the host cell cytoplasm because they have their own DNA-dependant RNA polymerase
35
What do double stranded RNA viruses require?
RNA-dependent RNA polymerases
36
What does the RNA-dependant RNA polymerase do with RNA viruses?
Acts a transcriptase to transcribe mRNA and a replicase to replicate the viral genome
37
Where do most RNA viruses complete their replication?
In the host cell cytoplasm, but some (influenza) are transcribed in the nucleus
38
Where do RNA viruses get RNA-dependant RNA polymerases?
They bring their own
39
What does a transcriptase to?
Transcribes mRNA
40
What does a replicase do?
Replicates the viral genome
41
What is the main characteristic of Retroviruses?
They have an RNA genome that directs the formation of a DNA molecule
42
What machinery is used with retroviruses?
The enzyme reverse transcriptase
43
What does reverse transcriptase do?
It copies viral RNA into DNA (RNA dependant DNA polymerase)
44
What is done with the resulting DNA in retroviruses?
It is integrated into the host DNA (then transcribed into mRNA and translated into protein by host enzymes)
45
Do retroviruses kill their host cells?
Most don't immediately kill their host cells, but rather infected host cells can continue to replicate producing daughter cells with integrated proviral DNA
46
Where does the reverse transcriptase for retroviruses come from?
The virus and not the host
47
What do vaccines consist of?
Live-attenuated or killed viruses, or viral proteins or mRNA
48
When can antiviral drugs exert actions?
``` At several stages of viral replication including •viral entry •nucleic acid synthesis •protein synthesis •viral packaging •virion release ```
49
What can Combination therapy result in?
Greater clinical effectiveness against viral infections and can also prevent or delay the emergence of resistance
50
What does it mean for anti-viral drugs to be virustatic?
They are only active against replicating viruses and do not affect latent viruses
51
What is an example of an Anti-Herpes Drug?
Acyclovir
52
How does Acyclovir work?
It is a nucleoside analog and lacks the hydroxyl group important for forming the backbone and blocks the lifecycle of the virus because newly synthesized DNA is inactive
53
Why doesn't Acyclovir affect the human genome?
Because it must be phosphorylated to acyclovir-triphosphate to be incorporated into viral DNA and can only be added by herpes-simplex virus thymidine kinase
54
What can Acyclovir resistance in herpes be caused by?
* Impaired production of thymidine kinase * Altered thymidine kinase substrate specificity * Altered viral DNA polymerase
55
What is HIV?
A lentivirus that lead to chronic persistent infection with gradual onset of clinical symptoms
56
Which cells does HIV infect?
CD4+ T cells
57
What happens when CD4+ T cells decline below a critical level?
Cell mediated immunity is lost and the body become susceptible to opportunistic infections
58
What kind of virus is HIV?
A retrovirus
59
What do people with HIV die from?
They don't die from HIV, they die from infections that they cant fight off because they have no more CD4+ cells
60
What does current HIV treatment usually involve?
3 or more antiretroviral drugs
61
What is HAART?
Highly active antiretroviral therapy involving drug combinations that can slow or reverse the increases in viral RNA load that normally accompany progression of disease
62
What does HIV infection begin with?
Attachment of HIV envelope proteins called gp120 to CD4 and CCR5 receptors on T-cells
63
How do HIV entry inhibitors work?
They interfere with binding, fusion and entry of an HIV virion into a human cells
64
What is an example of an entry inhibitor for HIV?
Maraviroc
65
How does Maraviroc work?
It is a CCR5 receptor antagonist so it interferes with HIV binding to T cell
66
How does HIV reverse transcriptase enzyme synthesize DNA?
From HIV RNA using nucleosides in the host T-cell (RNA dependant DNA polymerases)
67
What are NRTI?
Small molecule drugs that are similar to the host nucleosides and are incorporated into new HIV DNA chain but they lack the 3' hydroxyl group from attachment of the next nucleoside
68
What is integrase?
A viral enzyme that inserts viral genome into the DNA of the host cell
69
What do Integrase inhibitors do?
Block the action of integrase to inhibit HIV proliferation
70
What is an example of an Integrase inhibitor?
Raltegravir
71
How does Raltegravir work?
Blocks the action of integrase to inhibit HIV proliferation
72
What is dependant on aspartate proteases?
Assembly of infection HIV virions
73
What do Aspartate Proteases do?
Cleaves precursor proteins to form the final structural proteins of the mature virion core
74
What are HIV protease inhibitors based on?
Molecular characterization of the active site of the viral enzyme
75
What are protease inhibitors used in combination with?
Reverse transcriptase inhibitors
76
What does the M2 protein do in terms of influenza?
Functions as a proton ion channel required at the onset of infection to permit acidification of the virus core which activates viral RNA transcriptase
77
What is Amantadine used to treat?
Influenza
78
What does Amantadine do?
Blocks proton transfer through M2, thus blocking acidification and the initiation of viral transcription
79
What Amantadine prophylactic against?
Influenza A and not B and can reduce the duration of symptoms if given within 48 hours after contact
80
What does Zanamivir treat?
Influenza
81
What is Zanamivir an inhibitor of?
Neuraminidases produced by influenza A and B
82
What do Neuraminidases do?
Cleave sialic acid residues from viral proteins that enable virus to be released from the host cell

Pharm (31 decks)

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