lecture 28 Flashcards
(6 cards)
1
Q
how many people have hearing loss
A
5% of the population (450 million)
predicted 2.5 billion by 2050
2
Q
types of hearing loss
A
conductive
- fluid
- foreign objects
- surfers ear
- allergies
- earwax
sensorineural
- ageing
- ototoxic side effects
- noise damage
3
Q
hearing loss treatment options
A
Hearing aids
cochlear implants
assisted listening devices
speech in noise training
outer/middle ear surgery
4
Q
future treatments
A
stem cell therapies
optogenetics
electrode modification
gene/drug therapies
5
Q
what is an effective gene therapy
A
otoferlin
6
Q
what does otoferlin gene therepy do
A
Ca2+ sensitive and plays an important role in vesicle docking and recycling at ribbon synapse
they insert it via fenestration in the stapes footplate this modifies genes in the whole cochlea
