Lecture 29: Neonatal Immunity & Immunosenescence Flashcards
(39 cards)
occurs in aging animals, refers to a gradual deterioration of the function of the immune system
Immunosenescence
when do pigs get NK cells
not until they are several weeks old
when can eggs be vaccinated
18 days
- Marek’s disease
- Newcastle disease
- Coccidiosis
at what time in gestation are calves able to distinguish self from non-self
73 days - Rotavirus
93 days - Parvovirus
120 days -parainfluenza
at what time in gestation are foals able to demonstrate cell-mediated response
79 days
at what time in gestation does VDJ rearrangement occur in pigs
30 days
fetal puppies can reject allografts at ____ days
45
intrauterine injection of antigen into puppy fetus before ___ days can induce tolerance
42 days
opossums are completely reliant on passive immunity until they are how old
7 days
infection of fetal calf with BVD between ____-_____days causes tolerance and persistent infection
50-120 days
shedding virus
infection of cow with BVD up to _____days causes abortion
50
two forms of BVD
cytopathic
non-cytopathic *can cause persistent infection
when does mucosal disease occur
when a persistently infected animal (non-cytopathic) gets infected w/ cytopathic BVD virus
cytopathic BVD infection causes what in fetal calves
congenital abnormalities
neonatal immune responses are more often …
Th2
immunization through the passive transfer of specific antibody from an immunized individual to a non-immunized individual
Passive Immunization
transfer of immunity by the transfer of immune cells from one individual to another
adoptive transfer
active immunization
immunization by direct administration of an antigen (Vaccine)
in an epitheliochorial placenta, how many layers separate maternal and fetal blood
6
in species with epitheliochorial placenta (pigs, horses), is there any prepartum IgG transfers to foal
no, IgG comes from colostrum
in domestic species, ___ makes up 65-90% of antibody content
IgG
also IgA, IgM, IgE
in primates, what antibody is predominate in colostrum and milk
IgA
in pigs and horses, what antibody predominates in colostrum and what in milk
antibody - IgG
milk - IgA
in ruminants, what antibody predominates in colostrum and milk
IgG
